chapter 45 TB

Question 1

drug regimen

Answer 1

therapy must contain multiple drugs- usually four (INH, RIF, EMB, PZA)until sensitivity comes back
-drugs must be taken regularly
-therapy must continue for longer period of time
2 phases of tx: initial-2 months (sensitivity comes back may be given different regimen); continuation: 4-7 months of therapy

Question 2

tx for speciality patient groups

Answer 2

pregnant/lactation: tx with INH and RIF, pyroxidine 25 mg/day; INH increased risk of hepatitis
pediatric: may progress to milary TB or CNS dz, INH and RIF, pyroxidine 25 mg/day
HIV positive: may not have positive PPD, extrapulmonary TB common, tx 4 drug regime

Question 3

prophylactic tx

Answer 3

• PPD positive but no symptoms
• INH only for 3-4 months
• report to health department

Question 4

pathophysiology

Answer 4

• caused by m. tuberculosis, slowly growing
• inhaled into alveolus and spreads from lungs
• spread by aerosolization or lung secretions