chapter 24 oxazolidinones

Question 1

pharmacodynamics of oxalodinones

Answer 1

• inhibits ribosomal protein synthesis

- most effective against aerobic gram-positive bacteria

Question 2

pharmacokinetics

Answer 2

-po well absorbed
-does not use CYP450
ADRs: diarrhea, head ache, nausea, myelosupression

Question 3

keep in mind when prescribing/administering oxalodinones (Z.Y.V.O.X.)

Answer 3

Z: zero drug additives in IV
Y: tYramine foods avoid
V: VRE/MRSA
O: pO dosing=IV
X: oXalodin abx

Question 4

clinical uses of oxalodinones

Answer 4

• pneumonia
• complicated skin infections (VRE/MRSA)
• very expensive

Question 5

oxazolidinones

Answer 5

• linezolid (zyvox)

- completely synthetic-less chance of resistance occurring naturally