Chapter 24 Metronidazole/nitazoxanide

Question 1

ADRs and monitoring

Answer 1

• anorexia, n/v, abd pn, dizziness, headache, metallic taste
• don’t use metronidazole is 1st trimester
• monitor for leukopenia

Question 2

Pharmacodynamics

Answer 2

Metronidazole: used for both parasitic and bacterial; active against trichomonas vaginalis, entamoeba hystolytica, h.pylori, clostridium, c.diff.
Nitazoxinide: for giardiasis lamblia, cryptosporidium
Trinidazole: for amebiasis, giardiasis, trichomonas is