49. Precancerous lesions and cancer types of the breast, breast cancer screening

Question 1

49-1. precancerous lesions and cancer types of the breast

types of breast cancer

Answer 1

precancerous lesion
- ductal carcinoma in situ
- lobular carcinoma in situ
malignant tumor
- invasive ductal carcinoma
- invasive lobular carcinoma

Question 2

49-1. precancerous lesions and cancer types of the breast

characteristics of DCIS (2)

Answer 2

malignancy in duct without invasion

shows calcification

Question 3

49-1. precancerous lesions and cancer types of the breast

types of DCIS

Answer 3

comedo type : central necrosis with dystrophic calcification

paget disease : shows erythema with nipple ulcer

Question 4

49-1. precancerous lesions and cancer types of the breast

characteristics of lobular carcinoma in situ (2)

Answer 4

carcinoma in nodule, without invasion

shows dyscohesive cells without E-cadherin protein

Question 5

49-1. precancerous lesions and cancer types of the breast

epidemiology of invasive ductal carcinoma

Answer 5

most common type in invasive carcinoma of breast

Question 6

49-1. precancerous lesions and cancer types of the breast

morphologic features of invasive ductal carcinoma (2)

Answer 6

formation of mass

presence of duct in desmoplastic stroma

Question 7

49-1. precancerous lesions and cancer types of the breast

subtypes of invasive ductal carcinoma (4)

Answer 7

tubular carcinoma
mucinous carcinoma
inflammatory carcinoma
medullary carcinoma

Question 8

49-1. precancerous lesions and cancer types of the breast

characteristics, prognosis of tubular carcinoma

Answer 8

well differentiated tubule, lack of myoepithelial cells

good prognosis

Question 9

49-1. precancerous lesions and cancer types of the breast

characteristics, prognosis of mucinous carcinoma (3)

Answer 9

presence of abundant extracellular mucin
occur in elderly
good prognosis

Question 10

49-1. precancerous lesions and cancer types of the breast

characteristics, prognosis of inflammatory carcinoma

Answer 10

carcinoma in dermal lymphatics

bad prognosis

Question 11

49-1. precancerous lesions and cancer types of the breast

clinical manifestation of inflammatory carcinoma

Answer 11

inflamed, swollen breast due to blockage of lymphatic drainage

Question 12

49-1. precancerous lesions and cancer types of the breast

characteristics, prognosis of medullary carcinoma

Answer 12

composed of large, high grade cells

good prognosis

Question 13

49-1. precancerous lesions and cancer types of the breast

characteristics patterns of invasive lobular carcinoma

Answer 13

indian file pattern (single file pattern)

Question 14

49-1. precancerous lesions and cancer types of the breast

etiology of male breast cancer (2)

Answer 14

associated with BRCA2 mutation
klinefelter syndrome (47, XXY)

Question 15

49-2. breast cancer screening

prognostic factor of breast cancer

Answer 15

axillary lymph node as sentinel lymph node

Question 16

49-2. breast cancer screening

predictive factor of breast cancer (3)

Answer 16

estrogen receptor
progesterone receptor
HER2/Neu overexpression

Question 17

49-2. breast cancer screening

prognosis based on predictive factor

Answer 17

triple negative (ER, PR, HER2/Neu) tumor : prognosis prognosis

Question 18

49-2. breast cancer screening

genetic factor of hereditary breast cancer

Answer 18

BRCA1 : breast & ovarian carcinoma

BRCA2 : breast carcinoma in male

Question 19

49-2. breast cancer screening

most common organ of metastasis of breast cancer

Answer 19

bone, brain, lung, liver

Question 20

49-2. breast cancer screening

method of breast cancer screening

Answer 20

mammography (MRI)
palpitation : breast & axilla
self examination
fine needle aspiration biopsy