58. Non-neoplastic diseases of the thyroid gland Flashcards

1
Q

58-1. hyperthyroidism

etiology of hyperthyroidism (3)

A

Graves disease
multinodular goiter
hyperfunctioning adenoma

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2
Q

58-1. hyperthyroidism

etiology of graves disease

A

autoimmune disease stimulate TSH receptor

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3
Q

58-1. hyperthyroidism

clinical manifestation of graves disease (3)

A

exophthalmos
pretibial myxedema
thyrotoxicosis

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4
Q

58-1. hyperthyroidism

gross morphology of graves disease

A

diffuse enlargement of thyroid

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5
Q

58-1. hyperthyroidism

laboratory finding, radioactivity of graves disease

A

decreased serum TSH
increased serum T3, T4
increased iodine uptake (hot nodule)

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6
Q

58-1. hyperthyroidism

etiology of multinoduler goiter

A

iodine deficiency

  • endemic : iodine deficient soil
  • sporadic : mostly in puberty female
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7
Q

58-2. hypothyroidism

etiology of hypothyroidism

A

hashimoto thyroiditis

iodine deficiency

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8
Q

58-2. hypothyroidism

clinical manifestation of hypothyroidism

A

cretinism

myxedema

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9
Q

58-2. hypothyroidism

epidemiology, etiology of cretinism (3)

A

neonate, infant

maternal hypothyroidism, thyroid agenesis, maternal iodine deficiency

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10
Q

58-2. hypothyroidism

clinical manifestation of cretinism

A

skeletal system impairment

CNS development impairment : mental retardation

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11
Q

58-2. hypothyroidism

epidemiology, etiology of myxedema (2)

A

older children, adult

iodine deficiency, hashimoto thyroiditis

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12
Q

58-2. hypothyroidism

clinical manifestation of myxedema (9)

A
accumulation of GAG in soft tissue
slowed mental activity
muscle weakness
cold intolerance
fatigue
weight gain
bradycardia
hypercholesterolemia
constipation
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13
Q

58-3. thyroiditis

types of thyroiditis

A
Hashimoto thyroiditis
De quervain (subacute granulomatous) thyroiditis
Riedel fibrosing thyroiditis
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14
Q

58-3. thyroiditis

etiology of hashimoto thyroiditis

A

autoimmune destruction of thyroid, HLA-DR5

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15
Q

58-3. thyroiditis

gross morphology of hashimoto thyroiditis

A

painless enlargement of thyroid, symmetric, diffuse

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16
Q

58-3. thyroiditis

laboratory finding of hashimoto thyroiditis (2)

A

antithyroglobulin

antithyroid peroxidase antibody

17
Q

58-3. thyroiditis

hashimoto thyroiditis related tumor

A

increased risk of marginal zone M cell lymphoma

18
Q

58-3. thyroiditis

etiology of de quervain thyroiditis

A

viral infection

19
Q

58-3. thyroiditis

clinical feature, morphology of De quervain thyroiditis

A

transient hyperthyroidism

granulomatous formation

20
Q

58-3. thyroiditis

etiology, clinical feature of Riedel sclerosing thyroiditis

A

chronic inflammation

extensive fibrosis of thyroid