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Flashcards in 5.7 Other Hormones Deck (51):
0

Class of eicosanoids that cause vasodilation

Prostacyclins

1

Class of eicosanoids that cause vasoconstriction

Thromboxanes

2

Class of eicosanoids that cause renin release and bronchoconstriction

Prostaglandins

3

Class of eicosanoids that mediate inflammation and allergic reactions

Leukotrienes

4

eicosanoids are derived from
A. Lactic acid
B. Carbonic acid
C. Arachidonic acid

C. Arachidonic acid

5

Major pathway for liberating arachidonic acid

Phospholipase A2

Phospholipase C-B is an indirect pathway to obtain arachidonic acid

6

Primary source of leptin

Adipocytes

7

Leptin binds to
A. Gcpr receptor
B. cytokine receptor
C. Catalytic receptor

B. cytokine receptor

8

Which is a potent vasoconstrictor?
A. HETE
B. EET

A. HETE

9

HETE and ETE are responsible for RELEASE OF INTRACELLULAR CA STORES and INCREASED CELL PROLIFERATION.

TRUE OR FALSE.

TRUE

10

Inhibits food intake
A. Leptin
B. Ghrelin
C. Growth hormone
D. Prostaglandin

A. Leptin

11

Leptin stimulates: @-MSH; inhibits: _________

Lepton inhibits NPY cause this stimulate food intake

12

Which pair is correct
A. NPY- anorexigenic
B. @-MSH - orexigenic
C. AGRP - orexigenic

A. NPY- anorexigenic WRONG. NPT stimulates food intake, Ghrelin
B. @-MSH - orexigenic WRONG MSH inhibits food intake, Leptin
C. AGRP - orexigenic CORRECT AGRP stimulates food intake Ghrelin

13

Plays a role in tumor suppression and tumor metastasis
A. Prostaglandin
B. Leukotrienes
C. NO
D. Erythropoietin

C. NO

14

NO is synthesized from
A. Lysine
B. Tryptophan
C. Arginine

C. Arginine via NOS

15

Which is responsible for vasodilation
A. mNOS
B. eNOS
C. nNOS

A. mNOS - immune cell regulation
B. eNOS - CORRECT : vasodilation
C. nNOS - neural effect

16

Potent vasoconstrictor of endothelial cells

Endothelin

17

Which induces NO formation
A. ETA1
B. ETA2
C. ETB1
D. ETB2

A. ETA1 - vasoconstrictor, major isoform
B. ETA2 - does not exist
C. ETB1 - vasodilation, induces NO formation CORRECT
D. ETB2 - vasoconstrictor

18

Serotonin and melatonin are derived from
A. Tryptophan
B. Tyrosine
C. Arginine

A. Tryptophan

19

If one is blind this hormone level is always high because there is no circadian rhythm
A. Serotonin
B. Endothelin
C. Melatonin

C. Melatonin

20

Stimulates aldosterone secretion
A. Serotonin
B. Melatonin
C. Erythropoietin

A. Serotonin

21

Which hormone/s bind/s to cytokine receptors
A. Eicosanoids and NO
B. Endothelin
C. Ghrelin and eicosanoids
D. Serotonin and melatonin
E. Leptin and erythropoietin

E. Leptin and erythropoietin

22

Only stimulus that controls melatonin secretion

Light

23

Probable oxygen sensor for erythropoietin

Heme protein

24

Which state is the sensor ON
A. oxygenated
B. Deoxygenated

A. oxygenated - ON: O2 binds to Heme protein, decreased EPO production
B. Deoxygenated - OFF, less O2 binds to heme protein, increased EPO production

25

EPO synthesis is stimulated by
A. Polycythemia
B. Iron
C. Calcium
D. Hypoxemia

D. Hypoxemia

26

Biologically active metabolites derived from arachidonic acid are called __

Eicosanoids

27

Importance of eicosanoids

Important in mediating paraxrine and autocrine effects of inflammation

28

Enumerate major classes of eicosanoids

Prostaglandins
Prostacyclins
Thromboxanes
Leukotrienes

29

The enzyme actived by GPCR which releases arachidonic acid from membrane phospholipids

PLA2

30

Thromboxanes mediate these effects

Platelet aggregation
Vasoconstriction of small blood vessels

31

Prostacyclins have these effects

Inhibit platelet aggregation
Vasodilation

32

Also known as the cytochrome p450 pathway in synthesis of eicosanoids

Epoxygenase pathway

33

Product of epoxygenase pathway that is responsible tor cell proliferation and causes the release if intracellular calcium stores

HETE (hydroxyeicosatetranoic acid)

34

Degrades PG and TX

15-hydroxyprostaglandin dehydrogenase

35

Receptor for leptin

Cytokine receptor

36

Leptin is produced when there is a (lower or higher) quantity of fat

Higher. Tells the body to stop eating or gaining more fat.

37

Orexigenic hormone that stimulates hunger jn the brain

NPY or neuropeptide Y

38

Anorexigenic hormone that decreases food intake

a-MSH or alpha melanocyte stimulating hormone

39

The neurons in the __ of the hypothalamus regulate appetite and energy expenditure

Arcuate nucleus

40

Type of neuron in te arcuate nucleus which release a-MSH, decreasing food intake and increasing energy expensiture

POMC neurons

41

Tyoe of neuron in the arcuate nucleus which release ARGP and NPY, increasing food intake and reducing energy expenditure

AGRP-NPY neurons

42

Hormone which activates (+) AGRP-NPY neurons and stimulates food intake

Ghrelin

43

Hormone which inhibits (-) AGRP-NPY neurons and stimulates (+) POMC-CART neurons, thereby reducing food intake

Leptin

44

Nitric oxide is synthesized from

Arginine

45

Mechanism of action of nitric oxide: activates enzyme __ in the cytoplasm

Guanylyl cyclase

46

Is a vasoactive substance produced by the endothelium which is a potent vasoconstrictor agent in damaged blood vessels

Endothelin

47

The most important endothelin in regulating tone if vascular smooth muscle

Endothelin 1 (ET1)

48

When outside environment is dark, this hormone induces sleep, lowers body temp, and lowers metabolic rate

Melatonin

49

Primary stimulus for secretion of erythropoeitin

Decreased oxygen delivery

50

Type of receptor for EPO

Cytokine receptor