5.8 Female Reproductive Physiology Flashcards Preview

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Flashcards in 5.8 Female Reproductive Physiology Deck (47):
0

Atresia is common in what period of follicle development

Antral period

1

A class 4 follicle requires how many days to grow and develop to the preovulatory stage

About 50 days

2

Primordial, primary, and secondary follicles are classified as

Preantral follicles

3

Dominant follicle of the cycle appears to be selected from what class of follicles

Class 5 follicles

Note: requires about 20 days to develop to the ovulatory stage

4

Recruitment occurs even before ______

Onset of the present menstrual cycle

5

What does the theca cell lack that's the reason why it cant convert androsetenedione to eastradiol

Aromatase

6

Converts cgolesterol to pregnenolone

P450 scc

7

Major product of follicle in follicular phase

Estradiol

8

Major product of corpus luteum during luteal phase

Progesterone

9

A small primary oocyte arrested in the diplotene stage of meiosis

Primordial follicle

10

What provides nutrition to growing oocytes

Granulosa cells

11

T/F Primordial follicle has an independent blood supply

False- DOES NOT HAVE an independent blood supply

12

Most number of primordial follicles are seen during

Midgestation

13

As a woman ages, primordial follicles ______ in number

Decrease

14

Primordial follicles --->

Primary follicles

15

Transition hallmark of primordial follicle to primary follicle

1. From squamous to cuboidal
2. Acquisition of mitotic potential in the granulosa cells

16

Functional unit of the ovary

Ovarian follicle

17

When the antrums are produced, the follicles become dependent on __

Gonadotropins

18

During this period of folliculogenesis, FSH receptor expression occur

Primary follicle

19

The major product of theca cells

Androstenedione

20

Key regulator of steroidogenesis

LH

21

Hormones present during Follicular Phase

Estrogen
LH (at late stage)

22

Hormones present during Luteal Phase

Estrogen and Progesterone

23

Normal menstrual cycle

28 day cycle

24

Maintain a normal ovarian reserve by promoting the general health of the ovary

Pituitary gonadotropins

25

T/F rate at which resting primordial follicles enter the growth process appears to be independent of pituitary gonadotropins

True

26

The decision of resting follicles to enter the early growth phase is primarily dependent on ________

Intraovarian paracrine factors

27

Stimulator of FSH receptor expression include

FSH, activin, cAMP, TGF-beta

28

Develops its surrounding zona pellucida (extracellular matrix)

Primary Follicle

29

Structure penetrated by the sperm during fertilization

Zona pellucida

30

T/F Zona pellucida is specie-specific

True

31

When a secondary follicle acquires 3-6 layers of granulosa cells, it secretes ________ that induce _________ to differentiate into __________

1. Paracrine factors
2. Nearby Stroma Cells
3. Epitheloid Theca Cells

32

Formation of thecal layer

Mature Preantral Follicle

33

T/F As follicles develop they move outward

False- move inward

34

Thecal cells are analogous to

Testicular Leydig cells

35

Function of thecal cells

1. Express LH receptors
2.produce androgens

36

T/F Thecal cells express high levels of 17 beta-HSD

False- DO NOT express high levels of 17 beta-HSD

37

Characteristics of a dominant follicle

1. Secretes highest amount of estrogen
2. Most sensitive to FSH
3. Greatest number of receptors
4. Greatest mitotic activity and number of granulosa cells
5. More vascularized Theca cells

38

Theca Cells : ________
Leydig Cells : Testosterone

Androstenedione - major product of Theca cells

39

Although the they have the potential to produce hormones, ovarian follicles do not secrete ovarian hormones at this stage

Secondary follicular stage

40

In Antral Follicular Phase, what is the function of FSH

Growth of oocytes
Stimulate proliferation of granulosa cells
Induce expression of aromatase for the synthesis of estrogen

41

It takes ____ days for a primordial follicle to develop into a dominant follicle

85

42

In regulation of GnRH, what are the hormones for short feedback

FSH and LH

43

Hormones involved in ovulation the their levels

Decreased LH, Decreased Estrogen, Increased Progesterone

44

Phase and specific pattern of GnRH secretion needed for LH surge

Late Follicular Phase - highest frequency

45

FSH release is _______ than LH release during puberty and menopause

Greater

46

Preferential inhibition of FSH release during reproductive years is due to

Increased levels of estradiol and inhibin