Pathology - Bone/Soft Tissue Tumors

Question 1

Def: malignant cartilage tumor in the medulla of the pelvis or central skeleton in > 40 yo m

Answer 1

Chondrosarcoma

Question 2

Def: mass extending from metaphysis of bone w/ cartilage cap

Answer 2

Osteochondroma

Question 3

Def: tumor of osteoblasts > 2cm w/ bone pain that doesn’t get better w/ aspirin/NSAIDs

Answer 3

Osteoblastoma

Question 4

Sx’s: Onion-skin on X-ray

Answer 4

Ewing Sarcoma

Question 5

Def: benign tumor of osteoblasts in males < 25 yo in the cortex of long bones

Answer 5

Osteoid Osteoma

Question 6

Def: benign tumor on facial bones assc w/ Gardner syndrome

Answer 6

Osteoma

Question 7

Sx’s: painful enlarging mass in the pelvis or central skeleton

Answer 7

Chondrosarcoma

Question 8

Mutation assc w/ Chondroma

Answer 8

IDH1

Question 9

Hist: locally aggressive tumor that may recur

Answer 9

Giant cell tumor

Question 10

The cartilage in an Osteochondram can transform to…

Answer 10

Chondrosarcoma

Question 11

Def: Osteolytic (punched-out) lesions in bone

Answer 11

Metastatic tumors

Question 12

What is the MC 1˚ malignant bone tumor

Answer 12

Osteosarcoma

Question 13

What determines the prognosis of Chondrosarcoma

Answer 13

Grade

Question 14

Osteoblastic lesions are created by mets from what tumor

Answer 14

Prostatic carcinoma

Question 15

Sx’s: painful bony mass (< 2cm) that gets better w/ aspirin/NSAIDs

Answer 15

Osteoid Osteoma

Question 16

Ollier syndrome =

Answer 16

Chondroma w/ multiple lesions

Question 17

Mutations assc w/ teenage Osteosarcoma…

Answer 17

Rb TP53 INK4A MDM2/CDK4 HER2

Question 18

Hist: small, round blue cells (Homer-Wright rosettes) w/ scant cytoplasm

Answer 18

Ewing Sarcoma

Question 19

Def: malignant proliferation of osteoblasts in teenagers in the metaphysis of long bones

Answer 19

Osteosarcoma

Question 20

What commonly precedes Osteiod Osteomas

Answer 20

Sinus infection

Question 21

Mutation assc w/ Ewing Sarcoma

Answer 21

t(11;22) EWSR1-FLI1

Question 22

Maffucci variety =

Answer 22

Chondroma w/ increased risk of sarcoma

Question 23

Def: cartilage tumor arising in the medulla of small bones of the hands and feet

Answer 23

Chondroma

Question 24

Def: tumor of multinucleated giant cells and stromal cells in young adults in the epiphysis of long bones that makes “soap-bubble” appearance on X-ray

Answer 24

Giant cell tumor

Question 25

Def: malignant poorly differentiated cells from neuroectoderm in the diaphysis of long bones in pts < 20 yo

Answer 25

Ewing Sarcoma

Question 26

The MC cancers that mets to bone are…

Answer 26

Prostate Kidney Breast Lung

Question 27

Sx’s: one pain or Fx w/ swelling w/ sunburts appearance and Codman angle on X-ray

Answer 27

Osteosarcoma