Pathology - Disorders of Pigmentation and Melanocytes Flashcards
Def: small tan/brown macules d/t increased numbers of melanosomes that darken w/ sunlight exposure
Ephelis (Freckle)
What is Dysplastic Nevus Syndrome
AD disorder w/ formation of dysplastic Nevi that may progress to Melanoma *> 5mm, in non-sun exposed areas
What are the 4 variants of Melanoma
Superficial spreading - MC, radial growth Lentigo Malinga Melanoma - radial growth Nodular - early vertical growth Acral Lentiginous - on palms/soles of dark-skinned persons
Def: mask-like hyperpigmentation of the cheeks
Melasma
What are the Sx’s of Melanoma
A - asymmetry B - borders irregular C - color not uniform D - diameter > 6mm E - evolving
Which variant of Melanoma is not assc w/ UV light exposure
Acral Lentiginous
Melanoma is the MC…
Cause of death d/t skin cancer
What is Breslow thickness
Depth of extension of Melanoma into the dermis *Most important prognostic factor
Melasma is assc w/…
Pregnancy OCPs
What are melanocytes derived from
Neural crest cells
Hist: atypical melanocytes in nests and single cell arrays at the DE
Melanoma
Congenital Nevi are assc w/…
Hair
Def: Congenital lack of pigmentation d/t defective tyrosinase function
Albinism
Def: autoimmune destruction of melanocytes causing localized loss of skin pigmentation
Vitiligo
Def: benign neoplasm of melanocytes w/ a symmetric papule w/ sharp borders and evenly distributed color and < 6mm
Nevus (mole)
