Osteoporosis Pharmacology Flashcards
MOA: Calcitonin - Salmon
Inhibits osteoclasts
MOA: Aledronate, Risedronate, Ibandronate, Zoledronic acid
Analog of pyrophosphate causing inhibition of bone resorption by causing osteoclast apoptosis
MOA: Raloxifene
SERM agonist for E on bone
MOA: Teriparatide
Increases activity of osteoclasts and blasts - when given in bursts, osteoblast formation predominates
MOA: Denosumab
Inhibits RANKL decreasing formation of osteoclasts
MOA: Cinacalcet
Binds CASR on PT gland increasing sensitivity to ECM Ca and decreasing PTH
Clinical application: Calcitonin - Salmon
Established OP
Clinical application: Aledronate, Risedronate, Ibandronate, Zolendronic acid
PM OP OP in men Gluc-induced OP Paget disease of bone Hypercalcemia of Malignancy
Clinical application: Raloxifene
Prevention/Tx of PM OP
Clinical application: Teriparatide
PM OP, OP in men, Gluc-induced OP
Clinical application: Denosumab
High risk PM OP
Fx prevention in pts w/ bone mets
Major SE’s: Aledronate, Risedronate, Ibandronate
Esophagitis +/- ulceration
Atypical Fx’s
Major SE’s: Zolendronic acid
Osteonecrosis of the jaw
Major SE’s: Raloxifene
DVT
PE
Stroke
Pregnancy risk
Major SE’s: Denosumab
Delay Fx healing
Risk of new Fx
Osteonecrosis of the jaw
