Pathology - Joint Disease

Question 1

Hist: synovial fluid showing needle-shaped crystals w/ negative birefringence under polarized light (yellow color)

Answer 1

Gout

Question 2

How do Leukemia and Myeloproliferative disorders cause Gout

Answer 2

Increased cell turnover –> increased breakdown of DNA/RNA

Question 3

Sx’s: joint stiffness in the morning that worsens during the day

Answer 3

Osteoarthritis (DJD)

Question 4

Reiter syndrome and Psoriatic arthritis are associated w/ which joint disease

Answer 4

Seronegative Spondyloarthropathies

Question 5

What are 2 complications of RA

Answer 5

Anemia of chronic disease 2˚ amyloidosis

Question 6

What is a Pannus

Answer 6

Inflamed granulation tissue seen in RA

Question 7

Def: joint pain in a single joint d/t bacterial infection

Answer 7

Infectious Arthritis

Question 8

Def: deposition of monosodium urate crystals in tissues/joints

Answer 8

Gout

Question 9

Sx’s: morning stiffness that improves w/ activity, swan neck deformity and boutoniere deformity of the fingers, sparring of the DIP

Answer 9

Rheumatoid Arthritis

Question 10

Sx’s = warm joint w/ decreased ROM and an elevated ESR

Answer 10

Infectious Arthritis

Question 11

Def: chronic, systemic autoimmune disease in women ~ 40 yo

Answer 11

Rheumatoid Arthritis

Question 12

Sx’s: severe pain on the great toe (Podagra)

Answer 12

Acute gout

Question 13

What are some other Sx’s of Lesch-Nyhan syndrome

Answer 13

Mental retardation, self-mutilation

Question 14

Hist: Joint mice, eburnation, osteophyte formation

Answer 14

Osteoarthritis (DJD)

Question 15

Myofibroblasts cause what issues in RA

Answer 15

Ankylosis (fusion of joints) Dragging of joints

Question 16

Def: non-inflammatory degeneration of articular cartilage d/t wear and tear

Answer 16

Osteoarthritis (DJD)

Question 17

What is the MC location of pain in Infectious Arthritis

Answer 17

Knee

Question 18

Def: Arthritis + Urethritis + Conjunctivitis in young males

Answer 18

Reiter syndrome

Question 19

RA is associated w/ which HLA

Answer 19

HLA-DR4

Question 20

What are the MC sites of Osteoarthritis (DJD)

Answer 20

Hips Lumbar spine Knees PIP, DIP

Question 21

Def: deposition of Ca Pyrophosphate Dihydrate (CPPD)

Answer 21

Pseudogout

Question 22

Def: Tophi found in joints (white, chalky aggregates of uric acid crystals w/ fibrosis and giant cell reaction)

Answer 22

Chronic gout

Question 23

Sx’s: LBP and fusion of the vertebrae (bamboo spine)

Answer 23

Seronegative Spondyloarthropathies

Question 24

Def: Axial and peripheral joint involvement involving the DIP of the hands and feet creating “sausage” fingers and toes

Answer 24

Psoriatic Arthritis

Question 25

Def: IgM autoAb against Fc portion of IgG

Answer 25

Rheumatic factor

Question 26

What type of collagen is Hyaline cartilage

Answer 26

Type II

Question 27

What are the MC bacteria in adults and children in Infectious Arthritis

Answer 27

Children = N. Gonorrhoeae Older children/Adults = S. Aureus

Question 28

Def: F of PIP and E of DIP

Answer 28

Boutoniere deformity

Question 29

Seronegative Spondyloarthropathies are associated w/ which HLA

Answer 29

HLA-B27

Question 30

Hist: nodules w/ central zone of necrosis surrounded by epithelioid histiocytes arising in the skin and visceral organs

Answer 30

Rheumatoid nodules

Question 31

In what disease would you see Heberden and Bouchard nodes and what are they

Answer 31

Osteoarthritis (DJD) Heberden = enlargement of DIP Bouchard = enlargement of PIP

Question 32

How does Lesch-Nyhan syndrome cause Gout

Answer 32

X-linked deficiency of HGPRT –> decreased salvage of Hypoxanthine

Question 33

Def: Hyper E of PIP and F of DIP

Answer 33

Swan neck deformity

Question 34

What is the demographic for Seronegative Spondyloarthropathies

Answer 34

Young males

Question 35

Def: joint pain w/ no rheumatic factor and involvement of the axial skeleton (SI joints and spine)

Answer 35

Seronegative Spondyloarthropathies