Pathology - Blistering Dermatoses Flashcards
Sx’s: blisters on the skin w/ bullae that don’t rupture easily and sparing of the oral mucosa
Bullous Pemphigoid
IgG Abs against desmoglein in a type II HSTY RXN
Pemphigus Vulgaris
Hist: Central epidermal necrosis surrounded by erythema
Erythema Multiforme
What is TEN MC d/t
Adverse drug rxn
What is Toxic Epidermal Necrolysis (TEN)
Severe SJS w/ diffuse sloughing of skin, resembling a large burn
Dermatitis Herpetiformis is assc w/…
Celiac disease (d/t IgA)
IgG Abs against hemidesmosome components (BP180) of basement membrane
Bullous Pemphigoid
Hist: Acantholysis (separation) of the S. Spinosum from the S. Basalis creating a “tomb stone” appearance w/ IgG Ab’s making a “fish net” pattern
Pemphigus Vulgaris
Hist: IgG Abs arranged in a linear pattern along the basement membrane
Bullous Pehphigoid
What is Stevens-Johnson Syndrome (SJS)
Erythema Multiforme w/ oral/mucosal/lip involvement and fever
Def: autoimmune deposition of IgA at tips of dermal papillae
Dermatitis Herpetiformis
Def: autoimmune destruction of desmosomes b/w keratinocytes
Pemphigus Vulgaris
Def: autoimmune destruction of hemidesmosomes b/w S. Basalis and basement membrane
Bullous Pemphigoid
Def: HYST RXN assc w/ HSV creating a targetoid rash and bullae
Erythema Multiforme
Sx’s: vesicles on the skin and oral mucosa w/ bullae that rupture easily (Nikolsky sign)
Pemphigus Vulgaris
