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Zak, MSK 2 > Gout Pharmacology > Flashcards

Gout Pharmacology Flashcards

1
Q

MOA: Colchicine

A

Inhibits formation of microtubules preventing leukocyte movement

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2
Q

MOA: Allopurinol

A

Competitively inhibits XO causing HX and X excretion

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3
Q

MOA: Febuxostat

A

Inhibits XO causing HX and X excretion

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4
Q

MOA: Pegloticase

A

Converts uric acid to allantoin (more soluble)

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5
Q

MOA: Probenecid

A

Blocks urate reabsorption in kidney causing more excretion

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6
Q

Clinical application: Colchicine

A

Acute gout when NSAIDs are failing

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7
Q

Clinical application: Allopurinol

A

Recurrent gout

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8
Q

Clinical application: Febuxostat

A

Recurrent gout when pts can’t handle Allopurinol

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9
Q

Clinical application: Pegloticase

A

Chronic gout in pts refractory to other Tx

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10
Q

Clinical application: Probenecid

A

Underexcreters w/ GFR > 60 and NO stones

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Zak, MSK 2 (17 decks)

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