Wed Wk 4 Mixed 2 Flashcards
interstitial fibrosis w central lymphs and macros/scattered giant cells is myocardial __ aka Aschoff body
eventually replaced by fibrous scar tissue to form __
macros w lots of cytoplasm and central ribbon of chromatin is __ cell
diuretics and antibiotics can lead to _ myocarditis w eosinophilic infiltrate
__ enters into RA bw IVC/TC valve
__ w anything that inc size of RA
Misclassification bias affects __ groups to same extent
granuloma
MS
anitschowsky
hypersensitivity
Coronary sinus
enlarged
both
most common mutation of CFTR is deletion of Phenylalanine which results in improper post__
thus, targeted for __ and degredation
tx w L__ to correct folding defect
SGN innervates gluteus __/__ to abduct the hip
IGN innervates gluteus __ to extend the thigh
HepB transmission to fetus usually occurs during passage in __
SE of clozapine includes A, S, M, met syndrome
translational processing
proteasome
lumacaftor
medius/minimus
maximus
brith canal
agranulocytosis, seizure, myocarditis
SOB, upper lobe nodules, calcified rim of hilar LN w birefringent particles w surrounding fibrosis has __
SOB, ill defined nodular opacities w noncaseating granulomas think __
SF1 is a nuclear receptor regulating trxn of S, S__ development and repro
mutation in SF1/NR5A1 can then impair __ cells
CO2 is a potent __ of CNS
esp in ABP range of __ when ABG exert most powerful influence
hypocapnia results in VC and dec cerebral __
silicosis
Berrylosis
steroidogenesis, sexual
sertoli
vasodilator
60-140
perfusion
Edward syndrome assc w VSD/PDA, __ kidney, __ diverticulum/malrotation
Aqueous humor produced by __ into posterior chamber
flows through pupil and into S_ canal
drains into E, C veins or go through ciliary muscle in __ path
Open angle glaucoma has __ intraocular pressure
seen as large optic _ w loss of peripheral visual fields
tx w L__ is prostaglandin that inc outlfow
activated by __ in cornea to dec collagen content in uveoscleral outflow path
may inc pigment in _/__
horshoe, meckel
ciliary body
schlemm
episcleral, conjunctival
uveoscleral
high
cup
latanaprost
esterase
iris/eyelashes
CA inhib D__ dec AH prodxn
BB T__ dec AH prodxn
AA agonist B__ vc ciliary body to dec prodxn
gonadal arteries arise from __ aorta
__ artery supplies blood to anal canal, scrotum, penis
Hepatocyte necrosis is cellular __ and cytoplasmic emptying
may have __ necrosis to other dead hepatocytes
apoptosis w cell shrinkage and eosinophilia aka C__ body
w mononuclear inflammation, must think __
Dorzolamide
timolol
brimonidine
abdominal
internal pudendal
swelling
bridging
councilmn
viral hepatitis
Salmonella enters gut mucosa via __ by m cells and bacteria mediated endocytosis
proliferates in __ patches and may lead to bleeding
look for relative __ and HSM
potential comp is intestinal __
Familial hypocalciuric hypercalcemia is due to mutation in CaSR a transmembrane __ receptor
binding of Ca inhibits __ release
in CKD, hyperPTH activates __/_ which inc bone resorption
leads to osteo__ and eventually osteodystrophy like __
phagocytosis
peyers
bradycardia
GPCR
PTH
osteoclasts, osteocytes
penia
osteitis fibrosis cystica
carcinoid tumors arise from E__ cells of intestinal mucosa
PI3K activates Akt activates __ to trxn genes for cell survival, anti-apoptosis, angiogenesis
mTOR inhibited by __
In SCD, valine nonpolar AA creates a __ pocket to interact w nonpolar residue on other Hb molecule
this causes p__ and sickling
In HbC disease, a __ AA is substitued, thus no hydrophobic pocket forms
use __ in anaphylactic shock
inc PVR due to __
inc CO/contractility via __
inc bronchodilation via __
enterochromaffin
mTOR
PTEN
hydrophobic
polymerization
charged
EPI
A1
B1
B2
ALS leads to loss of motor neurons in CN __/__/_/__
mutation is in __
SE of carbamezepine is __ suppression and SIADH
K/F/M are NMDA antags
Felbamate is anti__
Memantine used for __
in preg, there is an shift towards __ state
lose protein __
best tx w L__ like enoxaparin as it does not cross the placenta
Factor Xa inhib A
use C/A for prevention of thrombotic events
5, 9,10,12
SOD1
bone marrow
ketamine, felbamate, memantine
convulsant
Alzheimer
hypercoagulable
S
LMH
apixiban
clopidigrel, aspirin
avoid H1 antags in elderly due to blockade of C, S, A pathways
MTC due to parafollicular __ secreting C cells
nest/sheet of P__ or spindle shaped cells w extracellular amyloid deposits
thus, stain w __ red
Papillary thyroid Ca has visible papillae w __ core
may see __ bodies and Orphan annie eyes and intranuclear inclusions
tall cell variant may show follicular __ lined w epithelial cells
Tall, crowded cells seen in __ dz
hyperactive resoprtion leads to __ of edges
__ thyoid cancer has pleomorphic cells w irregular giant/spindle cells
cholinergic, serotoninergic, alpha adrenergic
calcitonin
polygonal
Congo
fibrovascular
psamomma
hyperplasia
Graves dz
scalloping
anaplastic
thyroid follicle cells, epithelium, derived from __
Psoriasis has absent __ w overlying parakeratosis
Calcineurin activates __ to go to nucleus and release IL2
tx w calcineurin inhibs C/T
endoderm
granulomsa
NFAT
cyclosporine, tacrolimus
Metachromatic Leukodystrophy is deficiency in A__
C__ accumulates w PN and ataxia
Krabbe dz is G__ def
G__ accumulates, w optic atrophy, seizures, hypotonia
Fabry dz a G__ def w __ accumulation
neuro pain and dermatologic findings
Gaucher dz has G\_\_ accumulate def in B\_\_ w HSM, pancytopenia and bone pain
arylsyulfatase A
cerebroside sulfate
galactocerebrosidase
galactocerebroside
a galactosidase, Gb3
glucocerebroside
glucocerebrosidase
