Friday Wk 4 Mixed 3 Flashcards
lumpy bumpy appearance on IF is __
electron micro shows IC on __ side of BM
Dec ADAMTS13 is seen in __
uncleaved vWF __ w platelet trapping/activation
tx w __ exchange and GC/rituximab
DCCB cause edema due to inc capillary __ pressure
also seen in impaired venous return like __ side HF and VTE
Dec plasma oncotic pressure leads to __
dependent on __ level
high Na/Water retention leads to edema by diluting __
L__ obstruction precipitates edema
Edema only develops when resorptive capacity of __ tissues are overwhelmed
PSGN
epithelial
TTP
multimers
plasma
hydrostatic Right edema albumin plasma proteins lymphatic
lymphatic
PMN chemotactic agents include C5a, IL8, LB4 and 5__
C5a activates PMN, and M/E/B
infantile __ has CV sx w cyanosis/SOB/vomiting
Dry beriberi is _ sx
wet adds __ sx
HBsAg presence in hepatocytes shows granular, diffusely homogenous, pale __ cytoplasm (ground glass hepatocyte)
also look for M__ inclusions and acidophil bodies w balloon __
clumped, amorphous, eosinophilic intracytoplasmic inclusions of tangled intermedite filaments is _ body seen in alcohol hepatitis
strep agalactiae is CAMP pos in that it __ S aureus hemolysis
HETE
monocytes, eosinophils, basophils
Beriberi
PN
cardiovascular
eosinophilic
mononuclear
degeneration
Mallory
pyruvate must become __ via PC using acetyl coa
both lactate/alanine are released into bloodstream to go to __ and become glucose
T__ is necessary for eversion/dorsiflexion
T__ is necessary for foot inversion
G/S__ needed for plantar flexion
t1/2= .7 x Vd
CL
reproductive system differentiation goes w G to G to E development
oxaloacetate
liver
tibialis anterior
tibialis posterior
gastroc, soleus
gonadal
genital duct
external genital
Gonadal deveopment- primordial germ cells near yolk sac migrate towards G__
under influence of __ on Y chromo, male gonads produce testosterone/MIF
Ductal- MIF causes __ ducts to regress, w development of wolffian ducts
in females, lack of T/MIF leads to __ ducts regressing, while paramesonephric ducts proliferate
genitl tubercle forms __ in males, __ in femles
urogenital folds form ventral aspect of __ and labia minora in females
genital swellings become __ in males, __ in females
urogenital sinus forms B/U/P/B in males
B, U, lower vagina and Bartholin glands in females
genital ridge
SRY
paramesonephric
mesonephric
glans penis, glans clitoris
male penis
scrotum, labia majora
bladder, urethra, prostate, bulbourethral
bladder, urethra
Thiazide diuretics dec __ sec and inc insulin resistance
In tubular fluid/plasma ultrafiltrate graph, downward slope indicates __
upward slope indicates secretion/non__
top line is __/__/__
inulin is not _ in renal tubules, while some creatinine is, and most __ is secreted
Urea is line __ as it is poorly reabsorbed in PT and free filtered from GC
line 4 is __ as it is reabsorbed in PT
Line 5 is avidly reabsorbed G/A
insulin
reabsorption
reabsorbed
PAH, Creatinine, Inulin
secreted,
PAH
2
bicarb
glucose, amino acids
ovarian mass w small, cuboidal cells in sheets/follicles/rosettes is (call exner body) __ tumor
have pink center w __ nuclei
plump w __ to give it a yellow gross color
unilateral and large, secrete __ leading to endometrial hyperplasia
enlargement of __ can compress the esophagus and cause dysphagia
can view __ aorta posterior on TEE
Ascending aorta lies __ to R PA
Aortic arch travels above RPA and left __
left pulm artery found superior to left __
SVC formed by union of R/L __ veins
aortic arch vessels
B, C, S
granulosa/theca cell
coffee bean
lipids
estrogen/inhibin
LA
descending thoracic
posterior
bronchus
main bronchus
brachiocephalic
brachiocephalic, left common carotid, left subclavian
RBC have __ mutase enzyme, which converts 13BPG to 23BPG
this yields no __, but allows for O2 delivery to tissues
Tuberous sclerosis due to mutation in gene coded proteins H__ TSC1/2
__ indicates nephropathy in DM pt
C/L are nonselective A/B blockers
A wave is atrial \_\_ C wave is bulging of \_\_ X wave is atrial \_\_ V wave is inflow of \_\_ Y wave is passive filling of \_\_
Rapid y descent indicates __
origin is R, cardiac surgery or __
prominent a wave indicates __
bisphosphoglycerate
ATP
hamartin
microalbuminuria
carvedilol, labetalol
contraction TC valve relaxation venous blood ventricle
constrictive pericarditis
radiation, Tb
Hypertrophic cardiomyopathy
to dx HIV, use __ for screening
__ blot to confirm
use __ blot to look for restriction site mutations, as DNA fragment length is altered
M__ is like S/N blot
sequence is labeled w __ tag, w degree of fluorescence corresponding to mRNA expressed
myosin light chain kinase adds Phos to myosin __ in smooth muscle
Myosin ADP-phos complex binds __
ADP-phos is then __ after this crossbridge forms
contraction occurs, and new __ displaces myosin from actin
__ is first gen H1 blocker, also blocks 5HT1/5HT2
used for __ overdose
ELISA
western
Southern
microarray
fluorescent
light chain
actin
released
ATP
cyproheptadine
A__ is 2nd gen antipsychotic
Plasma cells in MM susceptible to effects of Proteosome inhibs like B__
inhibition leads to excess p__ proteins, inducing apoptosis of plasma cells
Waldenstrom Macroglobulinemia has __ spike
Hyper__ sx and no crab findings
MGUS is __ w no crab findings
spike due to inc __
intracellular proteins tagged for degredation via U__
broken down by __
this allows for presentation by __
aripipazole
bozetomib
proapoptotic
IgM
viscosity
asx
plasma cells
ubqiuitin ligase
proteosomes
MHC Class 1
think __ w gastrin levels that inc after secretin admin due to abnormal AC activation
causes P__ cell hyperplasia w PU formation and diarrhea
Secretin released by s cells of __
Somatostain released by __ cells of panc/GI
Beta endorphin is endogenous opioid derived from __
Type 1 collagen is predominant form in __
also in T, S, S, L
CDK4/6 w cyclin __/__ phosphorylate Rb to release E2F for trxn
hallmark of SLE is formation of ___ activating complement w depleted levels
gastrinoma
parietal
duodenum
D
POMC
osteoid
teeth, skin, sclera, ligaments
D/E
Auotantibodies
