25. Chemotherapy of Neoplastic Drugs IV

Question 1

A patient is is diagnosed with CML which anticancer drug will target the specific cancer defect?

A. Getifinib 
B. Erlotinib
C. Lapatinib
D. Trastuzumab 
E. Imatinib

RFA

Answer 1

Ans. E. So in this question you needed to know that CML is to a t(9:22) over expression of BCR-ABL and that Imatinib is a inhibitor of BCR-ABL tyrosine kinases

A. Gefitinib- EGFR tyrosine kinase inhibitor

B. Erlotinib- EGFR tyrosine kinase inhibitor

C. Lapatinib- EGFR & ERB2 tyrosine kinase inhibitor

D. Trastuzumab- ERB2 antibody

Question 2

A 47 year old postmenopausal woman is put on a medication to counter act breast cancer that works by reversibly inhibiting aromatase. Which medication has the woman been prescribed.

A. Letrozole
B. Exemestane
C. Fulverstrant
D. Goserelin 
E. Tamoxifen

RFA

Answer 2

Ans. A Letrozole- is a AI that works by reversibly binding to aromatase. Anastrozole works by the same action.

B. Exemestane- does inhibit Aromatase but it is irreversibly binds

C. Fulvestrant- binds to estrogen receptor and increases its degradation

D. Goserelin- is used to prevent Prostate cancer, it inhibits gonadotropin release.

E. Tamoxifen- is an antagonist of estrogen in the breast and agonist everywhere else.