6. Cholinergic Agonists and Antagonists II

Question 1

A 20 year old main has a history of chronic diarrhea. Celiac and Crohn’s tests are negative. He is diagnosed with IBS-D. Which antimuscarinic is the best course of treatment? (MG)

A. Atropine
B. Benztropine
C. Ipratropium
D. Oxybutynin
E. Hyoscyamine

Answer 1

E. Hyoscyamine

Antispasmotic for IBS

Question 2

A 44 year old female buys a virtual reality gaming console- the HTC Vive- for her children. She feels extremely nauseous while playing a game that simulates skiing downhill with great speed. What could you prescribe to alleviate her motion sickness? (MG)

A. Scopolamine
B. Benztropine
C. Oxybutynin
D. Dicyclomine
E. Hyoscyamine

Answer 2

A. Scopolamine

Question 3

A 56 year old undergoes a surgery and is administered Succinycholine during the surgery to relax the skeletal muscle. During the surgery the patient’s temperature spikes to 113 F and the operating surgeon say tell you to go grab the reversal drug. What drug should you grab to save the mans life?

A. Dantrolene
B. Hemicholinium-3 
C. Pilocarpine
D. Tolterodine 
E. Echothiophate

RFA

Answer 3

Ans. A. Dantrolene- the patient is suffering form Malignant hyperthermia due to excessive Ca release

B. Hemicholinium-3 inhibits acetylcholine synth. by blocking the CHT it is used as a research tool

C. Pilocarpine- a partial muscarinic agonist and is used to treat Glaucoma and Sjogren’s Syndrome

D. Tolterodine- is an antimuscarinic used to treat overactive bladder

E. Echothiophate- is a organophosphate and is rarely used from gluacoma

Question 4

A researcher is conducting studies on a drug that works by blocking the ACh-H antiporter. Which drug is the researcher observing?

A. Hemicholinium-3
B. Atropine 
C.Vesamicol 
D. Tubocurarine 
E. Botulinum Toxin 

RFA

Answer 4

Ans. C Vesamicol

A. Hemicholinium-3 is similar to Hemicholinium-3 but it blochs CHT

B. Atropine blocks Ach receptor in both synaptic and presynaptic

D. Tubocurarine- is a competitive antagonist nondepolarizing blocker

E. Botulinum Toxin inhibits the release of ACh

Question 5

Tubocurarine is given to a 65 y/o woman to relax her skeletal muscles before having a hip replacement. How does this medication work?

A. Nondepolaring blocker, competitive antagonist
B. Depolaring blocker, agonist
C. Antinicotinic ganglion blocker
D. Antagonist of nicotinic receptor
E. Muscarinic antagonist 

SZ

Answer 5

Ans. A

Nondepolaring blocker, competitive antagonist

Question 6

A ganglion blocker works on M2 receptors, what would be the effect?

A. Hypotension
B. Venodilation
C. Increase HR
D. Mydriasis
E. Xerostomia 

SZ

Answer 6

Ans. C Increase HR