8. Zöliakie Flashcards by Ian Paglione

Q

(Sprue)

Genetik

A

HLA-DQ2

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Q

(Sprue)

Differenzialdiagnose

A

Acrodermatitis enteropathica

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Q

(Sprue)

Acrodermatitis enteropathica: Ursache

A

partielle Zinkresorptionsstörung

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Q

(Sprue)

assoziierte Erkrankungen (3)

A

DM1
Trisomie 21
Autoimmunthyreoiditis

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Q

(Sprue)

Komplikation

A

EATL

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Q

(Sprue)

EATL

A

Enteropathie-assoziiertes T-Zell-Lymphom

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Q

(Sprue)

Symptome (2)

A

intestinale
extraintestinale

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Q

(Sprue)

intestinale Symptome (3)

A

abdominelle Beschwerden
Malabsorptionssyndrom
Stuhlveränderungen

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Q

(Sprue)

extraintestinales Symptom

A

Dermatitis herpetiformis Duhring

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Q

(Sprue)

Dermatitis herpetiformis Duhring: Charakteristik

A

herpetiforme pruriginöse erythematöse Plaques

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Q

(Sprue)

Labordiagnostik (2)

A

Gesamt-IgA
anti-tTG-IgA

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Q

(Sprue)

anti-tTG-IgA

A

anti-Transglutaminase IgA

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Q

(Sprue)

weitere mögliche Labordignostik

A

anti-tTG-IgG
anti-EmA-IgG
anti-dGP-IgG

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Q

(Sprue)

weitere mögliche Labordignostik: Indikation

A

bei IgA-Mangel und (-) anti-tTGA

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Q

(Sprue)

anti-tTG-IgG

A

anti-Transglutaminase-IgG

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Q

(Sprue)

anti-EmA-IgG

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A

anti-Endomysium-IgG

Q

(Sprue)

anti-dGP-IgG

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A

anti-deamidiertes Gliadinpeptide-IgG

Q

(Sprue)

Diagnosestellung: Goldstandard

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A

ÖGD mit Biopsie aus dem Duodenum

Q

(Sprue)

Biopsie: Befunde (3)

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A

Zottenatrophie
Kryptenhyperplasie
↑ Zahl an IEL

Q

(Sprue)

IEL

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A

intraepitheliale Lymphozyten

Q

(Sprue)

Therapie der Wahl

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A

GFD

Q

(Sprue)

GFD

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A

gluten freie Diät

Q

(Sprue)

GFD: Ziel

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A

< 10 mg Gluten/d