M3) Metabolic Response To Starvation Vs Injurt, Sepsis

Question 1

What can you see in urine that would be increased in starvation?

What is seen to be increased in the blood in starvation and what can this cause?

Answer 1

—-

Question 2

Anorexia nervosa - how would you treat this? What does survival depend on and why

Answer 2

—-

Question 3

What does insulin do?

Answer 3

—-

Question 4

In starvation, what happens to muscles and fat tissue?

Answer 4

—-

Question 5

Ketoacidosis - what are some causes of it? How can this happen / stimulated?

Answer 5

—-

Question 6

Ketoacidosis - physiology of how it comes to be and is used?

Answer 6

—-

Question 7

What is an example of a major ketone? also main thing — how can fasting ketosis be stabilised and explain this xx

Answer 7

Insulin stimulation. even though low glucose. Inhibits fatty acid release from adipose tissue. Can also directly inhibit lipolysis from ketones.

Question 8

How does the metabolic response differ between starvation and trauma / disease? Diff points. On back

Answer 8

Metabolic rate
Body fuels
Parody proteins
Urinary nitrogen
Weight loss

Question 9

What is sepsis, how does it present. What investigations would you do in suspected

Answer 9

—-

Question 10

Nutrition and critical illness - what is happening here and what is important to give pts?

Answer 10

—

Question 11

Lactic acidosis - what is the usual cause of this? Give some of examples that could lead to this state

Answer 11

Hypovolaemia, CF, sepsis, cardiopulmonary arrest.

Question 12

What happens to the body in the HYPERMETABOLIC response TO INJURY — such as trauma, surgery, critically ill

Answer 12

—-

Question 13

Why is glucose high in critical illness and how does this happen?

Answer 13

List what happens

Question 14

What can catecholamines do / affect in critical illness?

Answer 14

——

Question 15

What thing is that that causes protein and lipids to be used differently in illness? What happens here? PTO for hint

Answer 15

Lean muscle breakdown from TNF (pro inflammatory cytokine)

Question 16

— why does decreases in muscle mass contribute to insulin resistance?
—what are some effects of loosing just 10& of lean body mass?

Answer 16

Infection incr, wound healing delayfdgsethsr

Question 17

What are some endocrine complications — What is suppressed? What can be seen clinically

Answer 17

—-

Question 18

Endocrine complications of starvation — what is increased and what can be seen clinically

Answer 18

—-