Cancer) Treatment

Question 1

Give examples of some chemotherapeutic drugs

Pto for hint

Answer 1

Alkylating agents
Antimeytabolites
Mitotic inhibitors

Question 2

Methotrexate
Vincristine, vinblastine
Chloambucil mechlorethamine clyclophosphamide

What are they

Answer 2

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Question 3

Toxicity of anti cancer dugs — what cells are most sensitive and why

Answer 3

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Question 4

How do alkylating agents work

Give eg

Answer 4

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Question 5

How do vinca alkaloids work

Give eg

Answer 5

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Question 6

How do anthracyclins work

Give eg

Answer 6

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Question 7

What are some toxicity consequences of anti cancer drugs

Answer 7

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Question 8

What are some targeted cancer therapies

Answer 8

Monoclonal antibodies
Targeted therapies
Immunotherapies

Question 9

Give examples of monoclonal antibody drugs, how do they work

Answer 9

Rituximab, Obinutuzumab

Question 10

Rituximab. What is it How does it work. Give eg of similar drugs, what do they do

Answer 10

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Question 11

CML

What causes this
What is something that can be targeted by treatment

Answer 11

By imatinib specifically

Question 12

How can resistance to imatinib happen

Answer 12

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Question 13

What ares some next generation TKIs

Answer 13

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Question 14

Lung cancer NSCLC — what treatments can be effective and for what

Answer 14

EGFR mutation

ALK genetic lesions

Question 15

Gefetinib and Criztotinib

What do they target for NSCLC

Answer 15

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Question 16

What can be given to melanoma patients with b-raf mutation? How does it work

Answer 16

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Question 17

How can vemirafinib be helpful in melanoma? And when / how

Answer 17

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Question 18

How does ibrutinib work
What does it target
What happens as a result
Why is it not curative

Answer 18

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Question 19

Give eg of anti-angiogenic drug, how does it work and where is it useful

Answer 19

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Question 20

Bevacizumab

What is it how does it work what does it do

Answer 20

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Question 21

HER-2 — what is this in the context of breast cancer

What drug can target this

Answer 21

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Question 22

Traztuzumab

What is this and how does it work

Answer 22

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Question 23

What are some potential immune cell responses to tumours

Answer 23

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Question 24

How can tumours potentiate immune system

Answer 24

Th2, macrophage what to they do

Question 25

What types of tumour antigens are there

Answer 25

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Question 26

What are some areas in tumour cell and immune system interaction that could be stopped with checkpoint inhibitors

Answer 26

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Question 27

Ipilimubab - what does this do

Answer 27

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Question 28

How do chimeric antigen receptors T cell therapy work

Answer 28

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Question 29

What are the limitations of CAR-T cell therapy?

Answer 29

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