Cancer) Introuction, CLL

Question 1

What are the different types of leukemia and why does leukemia happen

Answer 1

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Question 2

CLL

What goes wrong here
Where do the tumours occur
What happens clinically

Answer 2

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Question 3

How can CLL presen, signs

Answer 3

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Question 4

Causes of CLL - what is the genetic basis of it

Answer 4

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Question 5

How is a diagnosis made for CLL

Answer 5

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Question 6

How can CLL affect cells in different parts of the body and how can treatment differ in these places

Answer 6

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Question 7

How are CLLs protected in the lymph nodes and how is their proliferation aided

Answer 7

What cells specifically

Question 8

What factors in patients are associated with higher or lower survival?

Answer 8

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Question 9

What mutation can specifically make CLL worse and how? Pto

Answer 9

IGHV mutation

Question 10

What is a good flow cytometry marker for CLL prognosis

What can help predict — the main prognostic feature soverall

Answer 10

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Question 11

What are current treatments available — give eg. Pto

Answer 11

Chemo - fludarabrine and bendamustine
Targeted therapy - ibrutinib, idelasib
Targeted antibodies - ABT199

Question 12

How do targeted antibodies work

Answer 12

Block CD20

Question 13

What is standar treatment for people who are young or fit without deletion 17p

Answer 13

FCR, BR

Question 14

What is first line for older patient or unfit without deletion 17p

Answer 14

BR

Question 15

Ibrutinib

What drug is this
What does its pattern of response show
Side effects?

Answer 15

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Question 16

What is CAR-T therapy how does yo work

Answer 16

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Expressing chimeric antigen receptor which binds to CD19
Cd19

Question 17

What are chimeric antigen receptors and fo they link in with CLL treatment

Answer 17

Enables redirection of engineered T cell subsets to a speciicefd target antigen