Cancer) Hallmarks Of Cancer Flashcards
What are the cellular hallmarks of cancer
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Evidence for genetic element to cancer
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What viral infections are associated with certain cancers? List
Cervical carcinoma?
adult T cell lymphoma
Burkitts lymphoma
Hepatocellular carcinoma
How do UV light and chemical carcinogens cause damage
How do mutations cause cancer, what must they do
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Oncogenes
What are they
How can they affect gene function, what do they change and do
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Examples of oncogenes - list what you van and what can they do
What is elevated in certain cancers
Growth factor receptors - erbB1 which encodes EGFR —RAS-MAPK pathway over active. Growth promoting genes over expressed.
erbB2 - breast
Her2
Ras
How does over expression of erbB2 lead to cancer
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Ras and cancer. What is the link here, what happens.
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Tumour suppressor genes
What are their properties, give examples of some and outlines them. Genetic inheritance?
BRCA1&2
Rb
p53 mutation — what is this and what happens here. Properties. Syndrome associated?
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APC - what is this what happens with this. Properties. What can this give rise to
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Famililial adenomatous polyposis coli - what is the genetic basis for this, how can it happen
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APC mutations - list all the ways this can happen
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How can oncogenes and tumour suppressor cells interact and give an example of their effect
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Autonomy from growth signals - what usually happens
Give an example of such a pathway
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