I&I) Sepsis Pthogenesis

Question 1

What are the problems with the SIRS criteria

Df of sepsis

Answer 1

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Question 2

What begins the immunopathology of sepsis - then what things are activated downstream of this

Answer 2

Ops — cd14 — tlr…

Question 3

What are the effects of pro-inflammatory cytokines during sepsis? List em

Answer 3

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Question 4

How do CVS changes come about.

What happens here — their stages and what at each on

Answer 4

Early distributive shock, hypovolaemic shock, cardiogenic shock

Question 5

Coagulation response in sepsis

What happens here and why

Answer 5

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Question 6

What are some metabolic changes

Answer 6

How can the other factors contribute and make things worse

Question 7

What are PAMPs how does this fit into sepsis. Give examples

What are PRRs, same as above

Answer 7

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Question 8

Difference between gram positive and negative in the way they cause sepsis.

How does G+ve bac lead to sepsis.

Give examples of bacteria

Answer 8

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Question 9

What is toxic shock syndrome how does it happen — toxin and bacteria

How does it present

Answer 9

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Question 10

When does toxic shock happen

What organisms causes it And in what patients

Answer 10

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Difference between strep pyogenes and staph aureus toxic shock??

Question 11

Immunpathogenesis of toxic shock — what causes it exactly

Answer 11

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Question 12

What are the difference between superantigen and exotoxins mediated sepsis and what is similar

Answer 12

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Question 13

Management of sepsis

How to assess severity (df of sepsis pls) . Hints

Answer 13

SOFA

QSOFA

Question 14

What are some red flags for sepsis

What is important to think about with antibiotic treatment

Answer 14

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