DEFECTS IN LEUKOCYTE FUNCTION Flashcards by Nicholas de Guzman | Brainscape

Q

what are the acquired diseases?

A

bone marrow suppression: tumors, radiation, chemotherapy

diabetes, malignancy, sepsis, chronic dialysis, anemia, malnutrition

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Q

what are the genetic diseases?

A

LAD-1,2

chronic granulomatous disease

myeloperoxidase deficiency

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Q

name the defect with this disease?

chronic granulomatous disease

A

decreased oxidative burst (phagocytic oxidase)

membrane bound (x-linked)
cyetoplasmic (autosomal recessive)

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Q

name the defect with this disease?

myeloperoxidase deficiency

A

decreased microbial killing due to defective MPO-H2O2 system

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