ABNORMAL WBC MORPHOLOGY

Question 1

types of abnormal WBC morphology?

Answer 1

Auer rods
toxic granulation
dohle inclusion bodies
hypersegmentation

Question 2

linear or spindle shaped red-purple inclusions in blasts or promyelocytes

derivatives of azurophilic granules

usually seen in pathologic conditions (AML)

Answer 2

Auer rods

Question 3

dark blue to purple cytoplasmic granules, peroxidase positive

found in severe infections or other toxic conditions

Answer 3

toxic granulation

Question 4

small oval inclusions in the peripheral cytoplasm of neutrophils which stain pale blue with wrights stain

remnants of free ribosomes or rough ER

frequently accompanies toxic granulation

Answer 4

dohle inclusion bodies

Question 5

normal neutrophils have 2-5 lobes connected by a thin chromosome strand

hypersegmentation occurs if:
>5% of neutrophils have 5 lobes or more

1% of neutrophils have 6 lobes or more

seen in?

Answer 5

hypersegmentation

megaloblastic anemia, B12 deficiency