Adrenergic Antagonists

Question 1

Which receptors do the following medication act on?
Doxazosin, Terazosin, Prazosin
Metoprolol, Atenolol
Propranolol
Labetalol, Carvedilol
Clonidine

Answer 1

Doxazosin, Terazosin, Prazosin - Alpha 1
Metoprolol, Atenolol - Beta 1
Propranolol - Beta 1, Beta 2
Labetalol, Carvedilol - Alpha 1, beta 1, beta 2
Clonidine - alpha 2 agonist

Question 2

Effect of adrenergic antagonists on the heart?

What receptor is acted on?

Answer 2

Decrease heart rate and contractility

Beta 1

Question 3

Effect of adrenergic antagonists on blood vessels?

What receptor is acted on?

Answer 3

Vasodilation - Alpha 1

Question 4

Effect of adrenergic antagonists on blood pressure?

What receptor is acted on?

Answer 4

Decrease BP - Alpha 1 and Beta 1

Alpha 2 agonist (clonidine) also decreases BP

Question 5

Effect of adrenergic antagonists on the lungs?

What receptor is acted on?

Answer 5

Bronchospasms - Beta 2

Question 6

Effect of adrenergic antagonists on the eyes?

What receptor is acted on?

Answer 6

Decrease aqueous humor production (decrease IOP) - Beta 1 and beta 2

Question 7

Effect of adrenergic antagonists on the GI/GU system?

What receptor is acted on?

Answer 7

Dry mouth - Alpha 2 agonist (clonidine)

Open Sphincter - alpha 1

Question 8

Effect of adrenergic antagonists on the CNS?

What receptor is acted on?

Answer 8

Stage fight, essential tremor - beta receptors