ANP pathway

Question 1

step 1

Answer 1

Increased stretch of baroreceptors in atria

Question 2

step 2

Answer 2

Atria release ANP into blood

Question 3

step 3

Answer 3

Effectors are bound by ANP

Question 4

What are the effectors bound by ANP?

Answer 4

Systemic blood vessels

Kidney

Question 5

Effects of ANP on kidney?

Answer 5

Increase GFR:
Increases urine output, which decreases blood volume, which decreases blood pressure
Increases loss of Na+/H2O: which decreases blood volume and BP
Decreases Renin release:
Which decreases ANG II release, which decreases release of Aldosterone/ADH

Question 6

Effects of ANP on systemic blood vessels

Answer 6

Vasodilation which decreases TPR which decreases BP

Question 7

Net effect of ANP

Answer 7

Decreased peripheral resistance
Decreased blood volume
Decreased blood pressure

Question 8

Is this a feedback loop?

Answer 8

Negative feedback loop. Reduced blood volume and pressure decreases stretch of atria until ANP is not released