Acetaminophen Flashcards Preview

Pharmacology > Acetaminophen > Flashcards

Flashcards in Acetaminophen Deck (12):
1

What is the chemical name for acetaminophen?

N-Acetyl-P-Aminophenol (APAP)

2

How is acetaminophen classified?

A "miscellaneous" analgesic - blocks COX-3

3

What is acetaminophen's (Tylenol) mechanism of action?

  • Inhibits COX3 - acts more upon CNS COX than peripheral COX (centrally)
  • Does not:
    • inhibit platelet aggregation
    • irritate GI tract
    • cause bronchoconstriction

4

Where is acetaminophen metabolized? And what about the metabolite? Half-life?

  • Metabolized by liver
  • Metabolite - hepatotoxic and nephrotoxic
  • Half-life - 1-4 hours

5

What are the uses for acetaminophen?

  • Analgesic
  • Antipyretic
  • Equally potent to aspirin

6

What is the #1 cause for liver failure in the US?

acetaminophen

7

What is the maximum dose of acetaminophen? And can it be used for anti-inflammatory?

  • Max dose: 4000 mg per day
  • Not anti-inflammatory

8

acetaminophen and aspirin are equally ___________ and equally __________. So why is acetaminophen less useful clinically?

  • efficacious (reduces same degree of pain)
  • potent (same dose in mg needed for effect)
  • Because it is not anti-inflammatory

9

What's the dosing with acetaminophen (Tylenol)?

  • Children: 10-15 mg/kg per dose every 4-6 hours as needed, don't exceed 2.6 g in 24 hours (5 doses)
  • Adults: 325-650 mg every 4-6 hours or 1000 mg 3-4 times/day, not to exceed 4 g per day

10

What is the max dose of acetaminophen in patients who regularly consume alcohol?

Not to exceed 2 grams per day

11

Avoid giving acetaminophen in patients with?

  • Liver disease/dysfunction
  • Alcoholism

12

What is a very important drug interaction of acetaminophen?

Warfarin (Coumadin)

It causes enhanced anticoagulation - increased bleeding risk