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Flashcards in Antivirals Deck (17)
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1

When is the best time to treat viral infections like recurrent herpes?

During the prodrome phase - The time before a viral outbreak (usually herpes) 

2

What is the primary herpetic infection vs recurrent?

  • Primary - Gingivostomatitis (ulcers along the gingival margin on palate that may spread to buccal mucosa, lips, tongue, floor of mouth, gingiva)
  • Recurrent - lip lesions, intraoral ulcers

3

What does treatment of viral infections include?

Combinations :

  • Antiviral drug
  • Topical anesthetics
  • Fluids, vitamins/minerals, rest

4

When is a viral infection contagious?

Vesicular lesions, vesicle breaks open.

They last about 10 days

5

What do antibiotics do to fungal infections?

They are ineffective for treatment of viral herpes lesions

6

Systemic corticosteroids are ___________ for use during viral illnesses.

Contraindicated - prolongs viral infection 

7

How are antivirals named, and what are the major antivirals?

"...vir" 

  • acyclovir (Zovirax) cream
  • acyclovir and hydrocortisone (Xerese)
  • penciclovir (Denavir)
  • famciclovir (Famvir)
  • valacyclovir (Valtrex)
  • docosonal (Abreva) = OTC
  • benzalkonium 0.13% in isopropyl alcohol (Viroxin) = professionally dispensed

 

8

How does acyclovir (Zovirax) work?

Inhibits viral DNA polymerase preferentially, inhibitting viral replication (drug is incorporated into viral DNA)

9

What drug is approved for used in immunocompromised patients for viral infections?

acyclovir (Zorivax)

10

What forms can acyclovir (Zovirax) be taken?

Systemic - recurrent mucosal and cutaneous herpes simplex infections

Topical - herpes labialis, mucocutaneous infections

11

What should be used cautiously if the patient is immunocompromised?

acyclovir and hydrocortisone - steroid component problemativ

12

What antiviral drugs can be used during prodrome phase to prevent the outbreak of herpes simplex?

  1. famciclovir (Famvir) - very expensive $$$
  2. valacyclovir (Valtrex) - 2 doses only, 12 hours apart

13

When valacyclovir is metabolized, what does the metabolite turn into?

acyclovir

14

How is docosanol (Abreva) used?

Topical - applied 5 times a day. more affordable

15

How does benzalkonium chloride 0.13% in isopropyl alcohol (Viroxyn) work?

Rub medicaiton into lesion (stings) - and it strips the lipid coating off the virus and kills it on contact in affected area. 

16

Viroxyn is considered a what?

Virucide

17

What are the side effects of all antiviral drugs taken systemically?

  • Bone marrow suppression
  • Blood dyscrasias (thrombocytopenia, leukopenia, aplastic anemia)