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Flashcards in Pain Terms Deck (18)
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1

What is an unpleasant sesory or emotional experience associated with actual or potential tissue damage, or described in terms of such damage called?

Pain

2

What is the absense of all sensory modalities called?

Anesthesia

3

What is the absence of pain in repsonse to a stimulus that is normall painful called?

Analgesia

4

What are endorphins?

Mainly concentrated in the central nervous system, activates opioid receptors, provides analgesia, eupohoria at MU receptor

5

What are Enkephalins?

(Greek - in the head)

First endorphin to be purified, activates delta receptor

6

What has a high affinity for kappa-opioid receptors?

Dynorphins

7

What type of pain are NSAIDS more effective against?

Dull, aching, inflammatory (Mild & Moderate) pain

8

What type of pain are opiates (narcotics) most effetive against?

Sharp, piercing, lancinations (severe) pain

9

Where do non-opioid analgesics act and what is their mechanism?

Act primarily at peripheral nerve endings

Mechanism - inhibits prostalgandin synthesis

10

Where do opioid analgesics act and what is their mechanism?

Act primarily within the CNS

Mechanism - depress the CNS which reduces response to pain (pain reaction)

11

What are the "true" analgesics?

NSAIDS - they stop the pain from where it is coming, where opiates diminish your awarness of pain, so they only act as analgesics 

12

What are the non-opioid analgesics?

  • Salicylates - aspirin
  • NSAIDS (ibuprofen, 22 total)
  • acetaminophen (Tylenol) 

13

What is classified as a "miscellaneous" analgesic? And what does it work on?

acetaminophen - works on COX3 in the CNS, and is not anti-inflammatory

14

What are some major functions of COX1?

Formation of cytoprotective prostaglandins and prostaglandins associated with inflammation. 

Regulates the amount of stomach acid produced - which is why aspirin or NSAIDS can cause GU bleeding (they decrease the ctyoprotective prostaglandins)

15

What are some important characteristics of COX2?

  • Produced when you experience trauma and need inflammatory response for healing
  • Drugs that block COX2 are primarily used for arthritis
  • No effect on the stomach
  • Celebrex 

16

What's important about COX3?

  • Works in the central nervous system
  • Suppresses prostaglandin synthesis
  • No anti-inflammatory effects
  • acetaminophen works this way 

17

How do we categorize NSAIDS?

Non-selective vs Selective 

18

What's the difference between non-selective and selective NSAIDS?

  • Non-selectives - block both COX-1, and COX-2
    • Most NSAIDS in use today
  • Selectives - block COX-2 only
    • Only one available - Celebrex