Can you take methotrexate with ibuprofen/aspirin?
- ibuprofen - inhibits breakdown of methotrexate causing toxicity
- aspirin - displaces MTX and interferes with its clearance, increasing serum concentrations and causing toxicity (bone marrow depression)
What cannot be taken with Lithium (used for bipolar disorder)?
- blocks excretion of lithium, resulting in toxicity
What does alcohol do to a patient when taking aspirin/NSAIDS?
Increases the risk for GI bleeding associated with aspirin and NSAIDS
Is there an interaction with antihypertensive medications and NSAIDS or aspirin?
Aspirin and NSAIDS decrease the effectiveness of many common antihypertensives - monitor BP if giving NSAIDS to patients tkaing BP meds
- Beta blockers
- ACE inhibitors