Acid-Base Regulation Flashcards Preview

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Flashcards in Acid-Base Regulation Deck (11):
1

primary process

an acid base process that is occurring independently

2

secondary process

a process that is occurring in response to a primary process as a compensatory mechanism, restoring pH towards normal

3

mixed primary process

more than one primary process occurring simultaneously

4

isohydric principle

the acid/base ratio of a buffer is determined by its Ka and [H+]

a change in [H+] changes the acid/base ratio of all buffers in a solution

5

Henderson Hasselbalch equation for bicarbonate

pH = pK' + log([HCO3-]/(0.03 x PCO2))

6

pH defenses

physical/chemical buffers (immediate)

respiratory compensation (minutes)

renal excretion or metabolism (long term solution)

7

What happens after an intravenous bolus of HCl in an artificially ventilated individual?

uncomplicated metabolic acidosis

pronounced decrease in [HCO3-]

transient increase in PaCO2

8

What happens after an intravenous bolus of HCO3- in an artifically ventilated individual?

pronounced increase in [HCO3-]

transient increase in PaCO2

9

nonbicarbonate buffer value

delta[HCO3-]/deltapH = nM/L/pH unit (Slykes)

10

response to metabolic acidosis

buffered by bicarbonate levels

stimulation of chemoreceptors (peripheral) and increased ventilation to compensate

11

response to primary metabolic alkalosis

respiratory acidosis through decreased ventilation

compensation is not complete because a pH difference is required for the reduction in ventilation

hypoventilation causes hypoxemia and carotid chemoreceptor will eventually counter the effect