Idiopathic Pulmonary Fibrosis Flashcards Preview

Pulmonary > Idiopathic Pulmonary Fibrosis > Flashcards

Flashcards in Idiopathic Pulmonary Fibrosis Deck (15):
1

idiopathic pulmonary fibrosis

unknown cause

involves lung only

chronic, progressive, irreversible, and usually lethal

2

pathogenesis

repeated stimulus leads to sequential lung injury and inflammation

the result is aberrant wound healing and fibrosis

inflammation is mediated by genetic factors and the Th1-Th2 balance

3

risk factors for IPF

smoking

farming and livestock

sand, stone or silica

wood dust

metal dust

4

clinical history of iPF

chronic cough for months - dry, nonproductive, unresponsive to medications

chronic dyspnea for months - progressive, starts as decreased effort tolerance and progresses to dyspnea at rest

5

phyiscal examination findings in IPF

clubbing

bilateral basal inspiratory crackles

absences of clues to suggest alternative etiology such as connective tissue disease

6

HRCT findings for IPF

subplerual, basal predominance

reticular abnormality

honeycominb with or without traction bronchiectasis

absence of features that are inconsistent with a UIP pattern

7

subacute hypersensitivity pneumonitis

8

pneumocystis pneumonia

9

alveolar proteinosis

10

sarcoidosis

11

histiocytosis

12

IPF

13

definite UIP pattern

evidence of fibrosis/architectural distortion with or without honeycombing in a predominantly subpleural/paraseptal location

fibrosis in a patchy distribution

fibroblast foci

absence of features suggesting not a UIP pattern

14

possible treatment of IPF

pirfenadone is theonly drug in trials that has been shown to have modest effect

15

non-pharmocologic therapies for IPF

oxygen supplementation for patients with hypoxia

pulmonary rehabilitation and structured exercise program

palliative care and symptom relief

lung transplantation