Flashcards in Acute and chronic inflammation Deck (38):
Name the causes of inflammation
Foreign bodies (splinter)
Ischaemia/infarction (heart attack)
Physical and chemical damage (acid burns)
Immune reactions (asthma)
The host response to tissue damage
Why does vasodilation occur in acute inflam?
To increase blood flow to injured area
What influences vasodilation?
Histamine and nitric acid
Increased permeability leads to what?
Oedema as fluids leaks into extravascular tissue
Vasodilation and increased permeability leads to...
If endothelial cells become injured or contract this causes what?
Define main aim of inflam
Recruit leukocytes to area of damage
Rbc in the middle wbc near the endothelial cells
Wbc going into extravascular space
Opsonin receptors recognise...
Microbes that have been coated with protein
Cytokine receptors respond to...
G protein coupled receptors recognise...
N-formymethionyl of bacteria as well as chemokine breakdown
Aim of acute inflam...
To resolve injury and promote healing
Chronic inflam is caused by
Acute inflam (not as common)
Immune mediated inflam
Prolonged exposure to toxic agen (atherosclerosis)
Tissue damage can occur when...
There is a long inflammatory reaction
What are the signs of attempted healing?
Connective tissue repair
Increased growth of small bv
Clinical signs of chronic inflam
Loss of function
What are the outcomes of acute inflam?
Healing by fibrosis
Signs and symptoms of chronic inflam?
Name the more severe side effects of chronic inflam
Which type of inflam is short lived and is a rapid response?
Which wbc is dominant in acute inflam?
Exaggerated inflame response can cause...
Poor immune responses can cause...
Medication for inflam...
No inflam response leads to...
Prolonged healing of wounds
+ Infection susceptibility
Acute appendicitis symptoms are...
*If CRP +100, not good*
Complications of acute appendicitis is...
Possible perforation leading to peritonitis/abscess formation
Septic arthritis symptoms are...
Possible causes of septic arthritis?
Recent surgery/trauma to knee
Treatment of septic arthritis?
In a minor injury such as a sprained ankle, is the inflam response of any use?
Rheumatoid arthritis is...
Chronic autoimmune inflammatory condition
During rheumatoid arthritis macrophages, lymphocytes and plasma attempt to remove foreign agents which causes...
Health tissue damage
Treatments of RA?
Name a disorder where initially, it is acute inflam but leads to chronic inflam...