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AdenoViridae Flashcards

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1
Q

Antigenic properties of adenoviruses

A
  • strong antigens
  • surface projections (fibers)
  • cross reaction with genera (serogroup)

sero group in canine AdenoV important for vaccination

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2
Q

Biological properties of adenovirus

A
  • wide distribution
  • diverse pathogenicity
  • oncogenic effect
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3
Q

Adenovirus genome and replicating enzyme used

A

doubles stranded DNA
uses own polymerase enzyme

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4
Q

Which famous canine disease does adenovirus cause?

A

Rubarths disease (1947)

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5
Q

Infectious canine hepatitis pathogen

A

CAdV-1

Canine Adeno Virus 1

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6
Q

FOx encephalitis pathogen

A

CAdV-1

Canine Adeno Virus 1

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7
Q

Occurance of CAdV-1

A

worldwide

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8
Q

CAdV-1 cause which disease?

A

Canine infectious hepatitis
fox encaphalitis

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9
Q

CAdV-1 pathogenesis

A

Intake: PO,conjunctiva
P. Rep: Tonsils, peyer’s patches
Viraemia
Liver,kidneys, eyes (bleu eye D)
brain (fox)
Shedding: urine (up to 6months)

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10
Q

What typoe of hypersensitivity can CAdV-1 cause

A

Type 3

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11
Q

Peracute clinical signs of CAdV-1

A

death within 1-2 days

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11
Q

clinical signs of acute CAdV-1

A

fever over 40° (3-5 dys)
(1-2 wks) oedema, convulsions, uveitis

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12
Q

in which case can the “blue eye disease” occur?

A

chronic case of CAdV-1

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13
Q

can CAdV-1 cause mucosal haemorrhages, coag problems?

A

yes

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14
Q

CAdV-1 pathology

A
  • haemorrages
  • enlarged, yellow liver
  • nuclear inclusion bodies (cowdry A)
  • gall bladder oedema
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15
Q

diagnostic method for CAdV-1

A
  • lab test (leucopenia, ALT,AST,ALP, bilirubinuria, DIC)
  • direct virus detection (PCR)
  • serology (can be positive in case of vaccination so not used)
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16
Q

Prevention of CAdV-1

A

attenuated (because of sero groups) and inactivated CAdV-1
attenuated CAdV-2
every 2 or 3 years

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17
Q

fox encaphalitis CS, diagnostic & DD

A
  • nerval signs
  • PCR
  • Rabies, distemper
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18
Q

Canine infectious laryngotracheitis causative agent

A

CAdV-2

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19
Q

what is Canine infectious laryngotracheitis

A

mild febrile disease of dogs with upper resp tract inflammation

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20
Q

clinical manifestation of Canine infectious laryngotracheitis in which dogs?

A

young mainly

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21
Q

Canine infectious laryngotracheitis is part of which disease

A

kennel cough

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22
Q

CS of Canine infectious laryngotracheitis

A

mild fever
nasal discharge
dry coughing

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23
Q

Canine infectious laryngotracheitis pathogenesis

A

air born inf
P . Rep: upper resp mucosa
rhinitis, laryngitis tracheobronchitis, bronchiolitis

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24
Canine infectious laryngotracheitis treatment
symptomatic Ab for co infections
25
Canine infectious laryngotracheitis prevention
- avoid crowded environment - polyvalent vaccines, from 2-3 month
26
AdenoVirus pneumoenteritis can affect
calves and sheeps and lambs raised intensively
27
what is AdenoVirus pneumoenteritis in calves
mild disease of 1-4 mO calves, with nasal discharges, coughing and diarrhea
27
AdenoVirus pneumoenteritis in calves causative agent
- Mastadenovirus genus - Barthadenovirus
28
Mastadenovirus replicates where?
bovine kidney
29
Barthadenovirus replicates where?
bovine testicules
30
AdenoVirus pneumoenteritis in calves pathogenesis
Intake: PO, airborne P rep: Multiplication in tonsils Viraemia - respiratory & enteric mucosal epithelia
31
AdenoVirus pneumoenteritis in calves CS age
6-8 wks or without colostrum: 3-4 wks
32
AdenoVirus pneumoenteritis in calves CS
- coughing - salivation - mild diarrhea Co infection: pneumonia
33
BAdV-10
in New Zealand & Norther Ireland haemorrhagic gastroenteritis, haemorrages in renal cortex, bladder & trachea
34
AdenoVirus pneumoenteritis in calves diagnostic
PCR
35
AdenoVirus pneumoenteritis in calves prevention
improve keeping conditions check colostrum uptake
36
Adenovirus pneumoenteritis in lambs pathogenesis
same as in calves
37
Adenovirus pneumoenteritis in lambs CS
mainly resp signs also haemorraghic-necrotic enteritis(OAdV-4)
38
Adenovirus pneumoenteritis in lambs frequent complication in rams
urolithiasis
39
Biotechnologies of adeno Viruses
used as vector to express inserted foreign genes (because big enough) - rabies vaccine for foxes - SARS-CoV-2 vaccine for hu
40
Which diseases are caused by Aviadenovirus genus
- Inclusion body hepatitis - Hepatitis hydropericardium syndrome - Quail Bronchitis - Avian gizzard erosion
41
Infection of Aviadenovirus
germinative & horizantal infection
42
Aviadenovirus diagnosis
virus detection antibody detection
43
method used for diagnosis of Aviadenovirus
PCR
44
Inclusion body hepatitis (IBH) susceptible species
chicken, turkey, pigeon & goose
45
Inclusion body hepatitis (IBH) can be seen with another syndrome
hydropericardium syndrome
46
Inclusion body hepatitis (IBH) affects mainly which animals
3-6 weeks old broilers
47
Inclusion body hepatitis (IBH) clinical signs
- anaemia - diarrhea weakness, similar to hepatitis, hydropericardium
48
Inclusion body hepatitis (IBH) histopath
nuclear inclusion bodies
49
Inclusion body hepatitis (IBH) pathology
liver: enlarged, pale, necrotic foci **heart & skeletal muscle: petechiae**
50
Hepatitis hydropericardium syndrome affects which animal
chicken | (goose, pigeon, duck, quail, ostrich)
51
Hepatitis hydropericardium syndrome can be seen in which age group
3-6 weeks broilers
52
Hepatitis hydropericardium syndrome was described first in
Pakistan then india (lychee disease)
53
Hepatitis hydropericardium syndrome pathology
- hydropericardium - lung oedema - enlarged kidney - pancreas : necrotic foci - heart skeletal muscl, haemorrhages
54
Hepatitis hydropericardium syndrome histopathology
nuclear inclusion bodies
55
Avian gizzard erosion (AGE) affects which animals & what age
Chicken, 3-6 weeks old | (rarely in layers and broiler parent flocks)
56
Avian gizzard erosion (AGE) clinical signs
- inappatence - decreased body weight gain & growth of flock is uneven - anaemia - decreased egg prod
57
Avian gizzard erosion (AGE) patho
**degenaration of keratin layer of gizzard** haemorrages and ulcers in the mucosal membrane
58
Avian gizzard erosion (AGE) histopath
nuclear inclusion bodies
59
Siadenovirus genus diseases
- haemorrhagic enteritis - avian adenoviral splenomegaly - marble spleen disease
60
Haemorrhagic enteritis (HEV) is seen in which animals
turkeys older than 4 weeks | (usually 6-11 week old growers)
61
Haemorrhagic enteritis (HEV) clinical signs
**immunosuppressive!** varaible (no signs but sudden death can appear) - bloody diarrhea
62
Haemorrhagic enteritis (HEV) type of infection
horizantal
63
Haemorrhagic enteritis (HEV) pathogenesis
- po/ fecal - intestinal epithelial cells - viraemia - bursa of fabricus, spleen, blood vessel damage - haemorrhages; immunusuppression
64
Haemorrhagic enteritis (HEV) diagnosis
PCR Elisa
65
Haemorrhagic enteritis (HEV) DD
- **Avian influenza, Newcastle disease** - turkey coronavirus
66
Haemorrhagic enteritis (HEV) prevention
attenuated, live vaccine
67
Marble spleen disease (MSD) is seen in which animals
Phaesants, 3-8 months old
68
Marble spleen disease (MSD) clinical signs
acute resp signs
69
Marble spleen disease (MSD) pathology
- enlarged, marbled spleen - lung oedema | (no intestinal lesion)
70
Avian adenovirus splenomegaly (AAS) general aspects
found in broilers similar to phaesant disease (not as severe) patho: liver & spleen enlarged
70
Barthadenovirus genus disease
egg drop syndrome
71
Egg drop Syndrome (EDS) causative agent
duck adenovirus duck/geese: only resp signs quails: same CS as chickens
72
Egg drop Syndrome (EDS) type of infection
- Vertical (in the egg) - Horizantal (with faeces)
73
Egg drop Syndrome (EDS) pathogenesis
- PO/germinative infection - rep: in lymphoid tissues & epithelial cells of oviduct/uterus - serous-mucous secretion, egg shell deformities - shedding: secretion + faeces in the cloaca
74
Egg drop Syndrome (EDS) clinical signs
- diarrhea (10-30% of flock) - decreased egg prod - soft/thin/pale shelled egg | peak of signs at laying (3-7 weeks)
75
Egg drop Syndrome (EDS) pathology
no characteristic signs (lesions in the oviduct)
76
Egg drop Syndrome (EDS) DD
decresed egg prod: avian influenza, newcastle disease egg shell deformities: infectious bronchitis, avian metapneumovirus
77
Egg drop Syndrome (EDS) vaccination
inactivated vaccine before laying periode | (yolk immunity --> lower number of infected bird via verticle route)
78
EDS in gosling
Acute respiratory disease rarely clinical signs
79
Acute respiratory disease in gosling caused by EDS patho
rhinitis, tracheobronchitis

Epi MT (16 decks)

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