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ParvoViridae Flashcards

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1
Q

Parvoviridae diameter

A

18-26 nm

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2
Q

Parvoviridae Shape

A

Icosahedral

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3
Q

Parvoviridae resistancy

(envelop ?)

A

Non-enveloped
- VERY strong resistancy

infectious for months in evironment

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4
Q

Parvoviridae genome

A

single stranded, linear DNA

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5
Q

Parvoviridae replication

A

uses cellular polymerase enzyme:
- rep in dividing cells or usage of helper viruses

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6
Q

Parvoviridae good or bad antigen?

A

Good antigen

Stenoxen

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7
Q

SMEDI stands for

A
  • stillbirth
  • mummification
  • embryonic death
  • infertility
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8
Q

Porcine parvovirus disease less common where?

A

Autralia and new-zealand

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9
Q

Pahtogenesis of Porcine parvovirus disease

A

intake: PO
Rep: in dividing cells
viraemia (1-7 dys)
fetus-across placenta (2weeks after inf)
shedding: feces, saliva & sperm

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9
Q

Porcine parvovirus disease structural proteins facts

A

3 structural prot: VP1,2&3
VP2: neutralizing

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10
Q

Porcine parvovirus disease 5 biotypes

A
  1. NADL-2: apatogen
  2. Classical PPV1: susceptible sows -SMEDI
  3. Kresse’s strain: dermatitis, death of immunocompetent fetus
  4. Strain with skin symptoms
  5. Coinfection with PCV-2: PMWS or PRDC
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11
Q

How long does maternal immunity protect against Porcine parvovirus disease

A

up to 6 months

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12
Q

Porcine parvovirus disease virus can cross the placenta in seropositive sows?

A

No

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13
Q

How long does the antibody production lasts for in case of Porcine parvovirus disease

A

9-10 months

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14
Q

Porcine parvovirus disease clinical signs

A

SMEDI

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15
Q

Porcine parvovirus disease clinical signs in pregnant sows

A
  • smaller than normal litter

PPV unlikely if at least 8 piglets alive

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16
Q

Porcine parvovirus disease clinical signs in Embryos and fetus

A
  • to 30 dys: death, resorption
  • 30-70dys: death -> mummification
  • after 70dys : weak & mummified fetus, myoclonia congenita
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17
Q

Can adults suffer from resp sign from PPV infection

A

rarely

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18
Q

Arbotus typical in PPV infected sows

A

no

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19
Q

after infection from PPV how long does immunity last for?

A

life long

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20
Q

what pb can a sow with life long immunity encounter later in life

A

repro problems every 3-4 years

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21
Q

pathology of PPV

A
  • not uniquely characteristic
  • subcutan haemorrages
  • mummification
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22
Q

serology diagnostics of Porcine parvovirus disease

A
  • VN
  • HAI
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23
Q

Direct virus detection diagnostics of Porcine parvovirus disease

A

PCR
HA
virus isolation

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24
diagnostics methods for Porcine parvovirus disease
- serology - direct virus detection
25
differential diagnostic of Porcine parvovirus disease
- PRRS - PCV2 - Leptospirosis - Brucellosis - CSF - AUjesky - FMD
26
vaccine of Porcine parvovirus disease
inactivated (live) combined
27
vaccination protocol of Porcine parvovirus disease
vaccination after 6 months of age, 1x or 2x before breeding repeat 1x every year
28
originally how many Porcine parvovirus disease serotype? now how many?
At first 1, now 7 PPV
29
Parvorirus enteritis of dogs infection between 3-8 weeks
sudden death myocardial damage high mortality within 2-3 days
30
Parvorirus enteritis of dogs infection after 8 weeks
Enteritis
31
Parvorirus enteritis of dogs infects whiwh animals
dog wolf fox canidae
32
which Canine parvovirus strain can infect cats?
CPV-2, only "a" subtypes | (10% of panleukopenia cases)
33
Pathogenesis of Parvorirus enteritis of dogs
intake: PO Rep: lymphoid tissue around throat, GALT Viraemia organs with fast cell division: crypt cells, myocardial (young animals), bone marrow, spleen, thymus, ln) massive shedding in faeces
33
Parvorirus enteritis of dogs clinical signs
- no spe signs - acute gastro-enteritis | outcome depends on age and immunity
34
Diagnostic method of Parvorirus enteritis of dogs
virus detection form feces Antibody detection
35
virus detection from feces of Parvorirus enteritis of dogs
rapid tests: positive for 10-15 days after live vaccines
36
Antibody detection of Parvorirus enteritis of dogs
rapid tests: sera (maternal immunity and vaccine!)
37
DD between Parvorirus enteritis of dogs and rotavirus
milder, haemorrhagic diarrhea is unusual
38
target of Parvorirus enteritis of dogs
crypts
39
target of coronavirus in dog Intestine
TIP of villi
40
target of rotavirus
villi
41
treatment of Parvorirus enteritis of dogs
treat clinical condition AB for sec inf quarantine hyperimmune sera
42
prevention of Parvorirus enteritis of dogs
vaccine: inactivated maternal Ab up to 3-4 months (hyperimminue sera before CS)
43
Cat Panleukopenia virus
CPV2-a
44
Cat Panleukopenia pathogenesis
intake: PO rep: lymphoid tissues around throat viraemia rep in lymphopid cells (leukopenia), crypt cells, myocardium, crosses placenta shedding from faeces
45
Cat Panleukopenia clinical signs
- high temperature - vomiting, diarrhea - young: may die before diarrhea | outcome depends on age and immunity
46
can cerebellar hypoplasia be a pathological finiding in CAPV infected cat
yes, caused by intrauterin or perinatal infection
47
Diagnotic method of Cat Panleukopenia
virus detection from feces: IF, PCR
48
DD of Cat Panleukopenia
- infectious rhinotracheitis (herpes virus) - infectious peritonis (coronavirus) - diarrhea (calicivirus)
49
Cat Panleukopenia prevention
inactivated vaccine maternal Ab 3-4 months (hyperimmune serum best before CS) | combined vaccine : rhinotracheitis, calicivirus
50
Mink Parvovirus enteritis pathogenesis
same as cats and dogs
50
Aleutian mink disease susceptible species
Mink, ferret | mink of aleutian genotype is more susceptible ## Footnote (lack in antigen presentation)
51
young mink CS in Aleutian mink disease
interstitial pneumonia
52
older mink CS in Aleutian mink disease
hypergammaglobulinaemia glomerulonephritis
53
Aleutian mink disease pathogenesis
intake: PO rep: lymphoid tissue around throat Viraemia organs with fast cell division shedding after 3/4 days
54
which typer of hypersensitivity is the Aleutian mink disease
typer 3 hypersensitivity
55
CS of aleutian mink disease
anorexia, bloddy faeces, nervous signs
56
lethality of aleutian mink disease
aleutian: 50% other colors : 5%
57
pathology observed in aleutian mink disease
- increased plasma cell count - glomerulonephritis - arteritis
58
detection of aleutian mink disease virus
PCR, Isolation
59
aleutian mink disease vaccine
no vaccine, general epidemiological preventive
60
Derzsy's disease other names
goose influenza goose hepatitis goose parvovirus enteritis
61
Derzsy's disease in which animals
goose and muskovy duck (duck able to shed the virus but have no clinical signs)
62
which family does the goose parvovirus come from?
dependoparvovirus (*does not need helper virus*)
63
Pathogenesis of goose parvovirus
intake: PO replication: small intestinal epithelium viraemia parenchymal organs shedding in faeces
64
spreading of goose parvovirus
horizontal vertical
65
horizontal spread of goose parvovirus
feces, recovered but long term shedding geese
66
Vertical spread of goose parvovirus
subclinical infection of parents infected old goose infected eggs: - embryo dies - hatches infected
67
after how much time does an infected goose with parvovirus has no clinical signs
5 weeks
68
Clinical signs of goose parvovirus in susceptible gooslings?
- cold like symptoms - diarrhea - convulsions - ascites | infection at hatching or day 1 ## Footnote death within 2-3 days
69
Clinical signs of goose parvovirus in partially protected goslings?
feather growing problems (receding hair) ascites | signs appear at the end of 2nd week
70
Clinical signs of goose parvovirus around day 13-15?
diarrhea, excicosis | (intact liver and heart)
71
Pathology of goose parvovirus?
- ascites (fibrinous) **- ball shaped heart, tiger stripes** - haemorrhages on membranes - hepatitis - pericarditis & perihepatitis - enteritis
72
DD of goose parvovirus
Riemerellosis Hemorrhagic Nephritis enteritis of geese
73
prevention of goose parvovirus
- obligatory to vaccinate (attenuated, inactivated or subunit) - Re-vaccinate layers, esp before end of laying period - passive protection (hyperimmune serum) for day old goslings
74
Duck parvovirus
similar to Derzsy BArbari duck, muscovy duck but does not infect geese
75
CS of duck parvovirus
- diarrhea - weakness in legs - nervous system - chronic: growth stops, feather growing pbs
76
Duck parvovirus pathology
Enlarged liver muscles look like cooked meat ball shaped heart ascites
77
Shrt beak and dwarfism syndrome is associated with which virus
duck parvovirus (muscovy duck) | genetic variant of MDPV & GPV
78
Polyomaviridae diameter
40-55nm
79
Polyomaviridae shape
icosahedral
80
Polyomaviridae resistancy
non enveloped: - VERY strong | onfectious for months in the environment
81
Polyomaviridae genome
double stranded, linear genome
82
Polyomaviridae structural proteins
VP1, VP2, VP3 (sometimes VP4) | replication associated proteins
83
which transcriptase does Polyomaviridae use?
Viral
84
Polyomaviridae is stenoxen?
yes, except birds
85
Polyomaviridae is oncogene?
yes
86
# French Molt Budgerigar Fledgling Disease Virus affected species
Parrots, falcon and finch
87
Budgerigar Fledgling Disease Virus CS and survival CS
Oedema, ascites, nephritis & hepatitis, haemorrages dvlpmt & growth stops, feather growing problems
88
Hemorrhagic Nephritis Enteritis of geese pathogenesis
Intake: PO, intranasal rep: lymphoid tissues around throat VIraemia virus rep: blood endothelium, bursa, kidney and intestinal epithelium shedding in faeces
89
Hemorrhagic Nephritis Enteritis of geese CS
- CNS (shaking of head and neck) - diarrhea - Chronic: uric acid crystals - elderly : sheds virus with no symptoms | CS starts few hours BEFORE death
90
Hemorrhagic Nephritis Enteritis of geese pathology
- oedema - ascitis - haemorrhagic nephritis - **gout** - necrotizing haemorrhagic enteritis - haemorrages around the body
91
Hemorrhagic Nephritis Enteritis of geese histopath!
- replication in endothelium
92
Hemorrhagic Nephritis Enteritis of geese prevention
farm specific vaccine to breeders vaccine (inactivated BFDV)

Epi MT (16 decks)

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