Flashcards in Adrenal condensed Deck (12)
Where are mineralocortiocoid receptors?
Kidneys, gut and glands (sweat and salivary)
Causes of adrenal insufficiency (primary and secondary)
Congenital Adrenal Hyperplasia (CAH)
Due to lack of ACTH stimulation
Iatrogenic (excess exogenous steroid)
Autoimmune diseases associated with Addisons
Type 1 DM, autoimmune thyroid disease, pernicious anaemia
Diagnosis of adrenal insufficiency
low Na, high K
SHORT SYNACTHEN TEST
Measure plasma cortisol before and 30 minutes after iv ACTH injection
Normal: baseline >250nmol/L, post ACTH >480
Should be (causes skin pigmentation)
Lack of libido
Tumour derived from the remnants of Rathke's pouch?
(headache, visual disturbances, hypopituitarism)
What do neuroendocrine cells secrete?
Features suggesting adrenocortical carcinoma?
Large size (>50g, often >20cm)
Haemorrhage and necrosis
Frequent mitoses, atypical mitoses
Lack of clear cells
Capsular or vascular invasion
In phaeochromoctyoma, what might cause a paroxysmal episode of hypertension?
-Palpation of tumour (e.g. feeling the tummy can cause release of adrenaline)