Flashcards in Train revision Deck (13):
Most common form of MODY?
Most common form, lowers the amount of insulin made by the pacnreas
Onset, treatment and complications of glucokinase MODY?
Onset at birth
Onset, treatment and complications of transcription factor mutation MODY? (e.g. HNF1 alpha)
Adolescence/young adult onset
Progressive hyperglycaemia1/3 diet, 1/3 OHA, 1/3 Insulin
Treatment proven to work really well in HNF1 alpha MODY?
Treatment for neontatal diabetes?
Requires insulin treatment within first 3 months of life
(remember you have transient and permanent neonatal diabetes though)
Transient neonatal diabetes
Diabetes usually diagnosed < 1 week
Resolves median 12 weeks
Permanent neonatal diabetes
Diabetes usually diagnosed 0 - 6 weeks
Lifelong treatment with insulin
This type of drug binds to the KATP channel in the pancreatic beta cell?
(stops hyperpolarisation = cell becomes depolarised = calcium enters = insulin released)
Mutations in Kir6.2 associated with what?
Associated with PNDM (permanent neonatal diabetes)