Treatment of Type 1 diabetes Flashcards Preview

Endocrinology > Treatment of Type 1 diabetes > Flashcards

Flashcards in Treatment of Type 1 diabetes Deck (12):
1

Useful discriminatory tests for T1DM?

GAD/anti-islet cell anitbodies
Ketones
C-peptide

2

C-peptide is usually found in the same concentration as...

Insulin

3

Trial which showed inverse relationship between HbA1c and risk of hypoglycaemic events?

DCCT

4

Hyperglycemia symptoms

Thirst, tiredness, blurred vision, weight loss, polyuria, nocturia, fungal infections
Cognitive, mood state, information processing, working memory
Potential risk of diabetic ketoacidosis (“DKA”)

5

Hypoglycemia symptoms

Pallor, sweating, tremor, palpitations, confusion, nausea, hunger.
Cognitive: tense-tiredness, information processing, working memory, coma

6

Starting dose for insulin for T1DM?

0.3 units/kg body weight
-divide around 50% prandial and 50% basal

7

Short acting insulin
-onset
-peak
-how long they last

Onset: 30-60 mins
Peak: 2-4 hours
Last:s 5-8 hours

8

Rapid acting insulin
-onset
-peak of action
-duration

Onset: 10-15 mins
Peak action: 60-90 mins
Duration: 4-5 hours

9

How much insulin per 10g carbs?

1 unit of insulin per 10g CHO

10

What type of insulin in a pump?

Short-acting

11

Limitations of insulin injection/pump

- into subcutaneous tissue
peak too slow to prevent post-meal
hyperglycaemic spike
-slow clearance

12

Non-insulin adjunct therapy in type 1 diabetes

Metformin
Leptin
GLP-1
?SGLT2
Anti-CD3 monoclonal antibody