Ovulation disorders Flashcards Preview

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Flashcards in Ovulation disorders Deck (19):
1

Surge in what triggers ovulation

LH

2

When does oestradiol peak?

Before ovulation

3

When does progesterone peak?

after ovulation

4

What is the progesterone challenge test?

Menstrual bleed in response to a five day course of progesterone: indicates oestrogen levels normal

5

Hypothalamic pituitary failure: gonadotropin levels and progesterone challenge test results?

Hypogonadotrophic hypogonadism
Low levels gonadotrophins
Oestrogen deficiency
Negative progesterone challenge test
Normal prolactin

6

Gonadotropin injections are associated with what

Higher multiple pregnancy rates

7

Management of hypothalamic anovulation

Stabilise weight
Pulsatile GnRH if hypog hypog
Gonadotropin daily injections

8

Gonadotropin and oestrogen levels in hypothalamic pituitary dysfunction?

Normal gonadotropins
Normal oestrogen levels

9

Insulin and PCOS

Body doesn't respond as well to insulin - glucose intolerance
Body just makes more insulin = hyperinsulinemia
Insulin lowers SHBG levels - hyperandrogenism

10

Treatment to induce ovulationin PCOS?

1) Clomifene citrate
2) Gonadotropin therapy
3) Laproscopic ovarian diathermy

11

Why would you give metformin in PCOS?

Improves insulin resistance
Restoration of menstruation and ovulation
May increase pregnancy rates

12

May not experience puberty/puberty may be incomplete and have symptoms associated with hypogonadism:

Men: decreased libido, erectile dysfunction, decreased muscle strength, diminished aggressiveness and strength
Women: amenorrhea, dyspareunia (because of decreased vaginal lubrication

Kallmann syndrome

13

Oligomenorrhea

Cycle more than 35 days
Less than 9 periods a year

14

Oligomenorrhea

Cycle more than 35 days
Less than 9 periods a year

15

1/1 - 1/10

Very common

16

1/10 - 1/100

Common

17

1/100 -1/1000

Uncommon

18

1/1000 - 1/10,000

Rare

19

Very rare