Adrenergic Drugs Class/mechanism

Question 1

Norepinephrine (levophed)

Answer 1

Nonselective agonist
Alpha 1 and 2
Beta 1

Question 2

Epinephrine

Answer 2

nonselective agonist
alpha 1
Beta 1 and 2
(Alpha 2)

Question 3

Amphetamine

Answer 3

indirect acting agonist

Increases release of NE and blocks reuptake.

Question 4

Isoproterenol (Isuprel)

Answer 4

Non-selective Beta agonist

Beta 1 and 2

Question 5

Dobutamine

Answer 5

Selective agonist

Beta 1

Question 6

Albuterol (Proventil)

Answer 6

Selective agonist

Beta 2

Question 7

Terbutaline (Brethine)

Answer 7

Selective agonist

Beta 2

Question 8

Phenylephrine (Neosynephrine)

Answer 8

Selective agonist

Alpha 1

Question 9

Clonidine (Catapres)

Answer 9

Selective agonist

CNS Alpha 2

Question 10

alpha-methyldopa (Aldomet)

Answer 10

Selective agonist

Metabolite (a-methylnorepinephrine) activates CNS alpha 2

Question 11

Fenoldopam (Corlopam)

Answer 11

Selective dopamine agonist

D1 only

Question 12

Dopamine

Answer 12

mixed acting (Direct and indirect) agonist
D1
alpha 1
Beta 1

Question 13

Phentolamine (Regitine)

Answer 13

Non-selective alpha antagonist

alpha 1 and 2

Question 14

Phenoxybenxamine (Dibenzyline)

Answer 14

Non-selective alpha antagonis
Alpha 1 and 2
non competitive covalent bond

Question 15

Prazosin (minipress)

Answer 15

selective antagonist

alpha 1

Question 16

Terazosin (hytrin)

Answer 16

selective antagonist

alpha 1

Question 17

Propanolol (inderal)

Answer 17

Nonselective beta antagonist (1st gen)

Beta 1 and 2

Question 18

Timolol (Betimol)

Answer 18

nonselective beta antagonist (1st gen)

Beta 1 and 2

Question 19

Metropolol (Lopressor)

Answer 19

Selective Beta antagonist (2nd gen)

Beta 1

Question 20

Atenolol (Tenormin)

Answer 20

Selective beta antagonist (2nd Gen)

Beta 1

Question 21

Bisoprolol (Zebeta)

Answer 21

Selective beta antagonist (2nd Gen)

Beta 1

Question 22

Carvedilol (Coreg)

Answer 22

Nonselective Beta antagonist (3rd Gen A)
Beta 1 and 2
plus alpha 1

Question 23

Labetalol (Trandate)

Answer 23

Nonselective beta antagonist (3rd gen A)
Beta 1 and 2
plus alpha 1

Question 24

Betaxolol (Kerlone)

Answer 24

Selective beta antagonist (3rd gen B)
Beta 1
Plus ca2+ channel blocking

Question 25

Tyramine

Answer 25

indirect acting agonist | increases CYTOPLASMIC NE reslease

Question 26

Cocaine

Answer 26

Prevent NE reuptake

Question 27

Guanethidine (Ismelin)

Answer 27

``` Nerve ending blocker False neurotransmitter (Vesicles become full of guanethidine rather than NE) ```

Question 28

Reserpine

Answer 28

Nerve ending blocker | Release of empty vesicles (NE is not taken into vesicles b/c it binds uptake transporter and stops it)

Question 29

Alpha-methyltyrosine (Metirosine)

Answer 29

Nerve ending blocker | Inhibit tyrosine hydroxylase (Decreases NE synthesis)

Question 30

Ephedrine (Pretz-D)

Answer 30

Mixed direct beta 2 and indirect agonist