Arthritis and Gout Drugs Class/Mechanism Flashcards Preview

Pharm Unit 2 MJC > Arthritis and Gout Drugs Class/Mechanism > Flashcards

Flashcards in Arthritis and Gout Drugs Class/Mechanism Deck (22)
1

Indomethacin

Non Selective NSAID
Eliminate pain; reduce inflammation (But does not slow disease progression)

2

Naproxen

Non Selective NSAID
Eliminate pain; reduce inflammation (But does not slow disease progression)

3

COX-2 inhibitors

Selective NSAID
Eliminate pain; reduce inflammation (But does not slow disease progression)

4

Quinolones

DMARD (Antimalarial)
Reduces T-cell activation and chemotaxis

5

Glucocorticoids

DMARD
1 inhibits PLA2 (Inhibiting release of arachidonic acid and, thus, formation of prostaglandins)
2 Inhibits cytokine production (which prevents indcution of COX 2)

6

Sulfasalazine

DMARD (immunosuppressive)
likely inhibition of IL-1 and TNF alpha release

7

Methotrexate

DMARD (Immunosuppressive)
1 Inhibition of AICAR transformylase and thymidylate synthase, with seconday effects on PMN chemotaxis
2 Causes adenosine accumulation, which inhibits inflammation

8

Leflunomide

DMARD (Immunosuppressive) Prodrug
Inhibits dihydoorotate dehydrogenase (involved in UMP synth) , which inhibits T-lymphocyte response to stimuli

9

Etanercept

Biological Response Modifier
Blocks binding of TNF to TNF receptor

10

Infliximab

Biological Response Modifier
Blocks binding of TNF to TNF receptor

11

Adalimumab

Biological Response Modifier
Blocks binding of TNF to TNF receptor

12

Golimumab

Biological Response Modifier
Blocks binding of TNF to TNF receptor

13

Certolizumab

Biological Response Modifier
Blocks binding of TNF to TNF receptor

14

Anakinra

BRM
IL-1 receptor antagonist

15

Tocilizumab

BRM
IL-6 receptor antagonist

16

Rituximab

BRM
Anti CD20 mAb, reduces circulating B-cells

17

Abatacept

BRM
Inhibits T-cell activation and induces T-cell apoptosis

18

Colchicine

Prevents tubulin polymerization and leads to inhibition of leukocyte migration, phagocytosis, and release of cytokines

19

Probenecid

Uricosuric Agent
Compete with urate at the anionic transport site of the renal tubule and inhibit urate reabsoption

20

Allopurinol

1 Reduces uric acid synthesis by inhibiting xanthine oxidase (competitive) which creates alloxanthine
2 alloxanthine is a non-competitive inhibitor of xanthine oxidase

21

Febuxostat

Non-purine, non competitive antagonist of xanthine oxidase

22

Pegloticase

Recombinant stabilized uricase
converts uric acid to allantoin