Malaria Drugs class and mechanism Flashcards Preview

Pharm Unit 2 MJC > Malaria Drugs class and mechanism > Flashcards

Flashcards in Malaria Drugs class and mechanism Deck (14)
1

Quinine

Quinolone derivative
Accumulate in parasites food vacuole, disrupt heme polymerization to hemozoin, yielding oxidative damage to membranes and digestive processes

2

Chloroquine

Quinolone derivative
Accumulate in parasites food vacuole, disrupt heme polymerization to hemozoin, yielding oxidative damage to membranes and digestive processes

3

Hydroxychloroquine

Quinolone derivative
Accumulate in parasites food vacuole, disrupt heme polymerization to hemozoin, yielding oxidative damage to membranes and digestive processes

4

mefloquine

Quinolone derivative
Accumulate in parasites food vacuole, disrupt heme polymerization to hemozoin, yielding oxidative damage to membranes and digestive processes

5

Primaquine

Quinolone derivative
Attacks in liver cell, forms quinolone-quinone intermediates that oxidize schizont membranes

6

Amantadine

Positive charge helps chloroquine overcome chloroquine resistant malaria vacuoles; point mutations against amantadine return bacteria to cholorquine sensitivity

7

Artesunate

Artemisinin compound
Specifically and selectively inhibits SERCA of p. falciparum

8

Artemether

Artemisinin compound
Specifically and selectively inhibits SERCA of p. falciparum

9

Lumefantine

aminoalcohol

10

Atovaquone

Napthalene
depolarizes parasitic mitochondria and inhibits their electron transport

11

Chloroguanide (Proguanil)

Antifolates
Dihydrofolate reductase inhibitors (Human and parasite pathway)

12

Tetracycline

Antibiotic

13

Clindamycin

Antibiotic

14

Doxycycline

Antibiotic