Arthritis and Gout Drugs Use and Side effects Flashcards
(22 cards)
Indomethacin
Use: rheumatoid arthritis; acute gouty arthritis
SE: gastric and duodenal ulcers
Naproxen
Use: Rheumatoid arthritis and acute gouty arthritis
SE: Gastric and duodenal ulcers
COX-2 inhibitors
Use: Superseding conventional NSAIDS for rheumatoid arthritis
SE: 50% fewer gastric and duodenal ulcers
Quinolones
Use: Rheumatoid arthritis, SLE
SE: Retinal damage
Glucocorticoids
Use: Rheumatoid arthritis; acute gouty arthritis (intraarticular injection for relief of acute monoarticular gout)
SE: Cushing symptoms
Sulfasalazine
Use: Rheumatoid arthritis
SE: N/V, skin rashes, neutropenia (30% of patients discontinue) headaches
Methotrexate
Use: Rheumatoid arthritis
SE: Nausea, stomatitis, hepatotoxicity (rare)
Leflunomide
Use: Rheumatoid arthritis
SE: Diarrhea, hepatotoxicity
Etanercept
Use: Rheumatoid arthritis
SE: none
Infliximab
Use: Rheumatoid arthritis
SE: Antigenic response to mouse Ab
Adalimumab
Use: Rheumatoid arthritis
Golimumab
Use: Rheumatoid arthritis
SE: Risk of infections
Certolizumab
Use: Rheumatoid arthritis
SE: Risk of infections
Anakinra
Use: Rheumatoid arthritis
Tocilizumab
Use: Rheumatoid arthritis
Rituximab
Use: Rheumatoid arthritis
SE: Infections; hypersensitivity reactions
Abatacept
Use: Rheumatoid arthritis
SE: Headaches and infections
Colchicine
Use: Acute gouty arthritis
SE: Low therapeutic index, long term use causes peripheral neuropathy and neutropenia. Nausea vomiting and toublesome diarrhea
Probenecid
Use: Chronic tophaceous gout
SE: Urate crystal mobilization and acute gouty arthritis and GI irritation
Allopurinol
Use: Chronic tophaceous gout
SE: Acute attacks of gouty arthritis early in treatment due to mobilization of crystals
Febuxostate
Use: Chronic Tophaceous gout
SE: Nausea, rash, arthralgias
Pegolitcase
Use: Chonic tophaceous gout
