Cholinomimetics (class/mechanism) Flashcards Preview

Pharm Unit 2 MJC > Cholinomimetics (class/mechanism) > Flashcards

Flashcards in Cholinomimetics (class/mechanism) Deck (12)
1

Bethanecol (urecholine)

Direct acting carbamic acid ester
Direct acting muscarinic cholinomimetic

2

Muscarine

Direct acting nonester alkaloid
DIrect acting muscarinic cholinomimetic

3

Pilocarpine (Salagen)

Direct acting nonester alkaloid
Direct acting muscarinic cholinomimetic (can be absorbed through the skin)

4

Cevimeline (Evoxac)

Direct acting nonester alkaloid
Direct acting muscarinic cholinomimetic (relatively specific for M3)

5

Nicotine (NRT)

Direct acting nonester alkaloid
direct acting nicotinic cholinomimetic

6

Neostigmine (prostigmin)

Indirect acting carbamate
AChE inhibitor (short acting)

7

Physostigmine (Eserine)

Indirect acting carbamate
AChE inhibitor (Short acting)

8

Donepezil (Aricept)

Indirect acting non-ester
AChE inhibitor (readily crosses BBB)

9

Edrophonium (Enlon)

indirect acting non-ester AChE inhibitor (v. Short acting)

10

Echothiophate (Phospholine)

indirect acting organophosphate
AChE inhibitor (long acting)

11

Pralidoxime (Protopam)

Strong nucleophile
regenerates phosphorylated AChE

12

Sarin

Very potent indirect acting organophosphate
AChE inhibitor (Very fast aging)