Adverse Drug Reactions Flashcards Preview

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Flashcards in Adverse Drug Reactions Deck (23):
1

Are adverse effects different from side effects?

Yes

2

What are the 6 classes of adverse effects.

A - augmented, dose dependent, predictable
B - bizarre, dose independent, unpredictable
C - chronic
D - delayed
E - end of treatment effects
F - failure of therapy

3

What are the 4 mechanisms of Type A effects.

1. Pre renal failure
2. Renal - tubular necrosis etc
3. Post renal
4. Drug interactions

4

What mechanism are diuretics and ACE Is involved in?

pre renal

5

What effect do ACE Is and ARBs have in terms of pre renal failure?

D and V

6

What effect do diuretics have in terms of pre renal failure?

dehydration

7

Give 3 examples of type a renal adverse effects.

gentamicin - sepsis
sulphonamides - RA
aspirin - CV disease

8

Give 2 examples of post renal effects.

methysergide - cluster headaches
chemotherapy - acute leukemias

9

What are 3 examples of Type B.

Drug rashes
Bone marrow aplasia - chloramphenicol antibiotic
Hepatic necrosis - halothane

10

Do Type B reactions have a high mortality?

YES

11

What type is associated with prolonged therapy?

Type C

12

Give 3 examples of type C effects.

Steroids - Cushings
Beta blockers - Diabetes
NSAIDs - hypertension

13

Can type C reactions be anticipated?

yes

14

Give 2 examples of Type D effects.

Secondary malignancies post chemotherapy
Craniofacial abnormalities in children of women taking isotretinoin

15

What type is associated with withdrawal?

TYPE E

16

Give an example of a a rebound effect in Type E

beta blocker withdrawal - angina

17

Give an example of a loss of physiological coping in Type E

steroid withdrawal and Addisonian crisis

18

Give an example of a mechanism dependent biological activity in Type E

anticonvulsant withdrawal/changes and epilepsy frequency

19

What does theophylline interact with?

macrolides

20

What do statins interact with?

macrolides
fibrates

21

What do TCAs interact with?

type 1 anti arrythmics

22

ACE Is increase hypoglycaemic effect of what?

sulfonylureas

23

Clopidigrel interacts with what?

PPIs