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Flashcards in Aggressive NHLs Deck (24):
1

origin of diffuse large b cell lymphomas

evolve from low grade lymphomas or arise de novo

2

cytogenetic hallmark of burkitt lymphoma

t(8;14)

3

clinical features of DLBCL

present with rapidly enlarging symptomatic mass at a single nodal or extra nodal site. painful. stage 4 isn't common.

4

most common extra nodal site of DLBCLs

GI tract. bone marrow and peripheral blood involvement is rare

5

morphology of DLBCLs

homogenous fish flesh tissue replacement (soft since lymphocytes aren't meant to stick together), presence of hemorrhage, necrosis, fibrosis

6

microscopic appearance of DLBCLs

diffuse architectural effacement, large cells, mitotically active, invasive, necrosis. can be centroblastic (oval vesicular nuclei, ugly cells) or immunoblastic (large nucleus, lots of cytoplasm)

7

international prognostic index for DLBCLs

do less well if >60, have elevated LDH, poor fitness, extensive disease on both sides of diaphragm, multiple extra nodal sites

8

GCB type of DLBCL

germinal center B cell type, express BCL6/10, tend to respond better to treatment

9

ABC type of DLBCL

activated B cell type, have traversed the germinal center, don't respond well to surgery

10

three types of burkitt lymphoma

endemic, sporadic, immunodeficiency associated

11

endemic BL

most common childhood malignancy in Africa, males more, always associated with EBV

12

sporadic BL

affects young adults, males more. sometimes associated with EBV

13

immunodeficiency associated BL

primarily seen in association with HIV. can be the initial manifestation of AIDS, sometimes with EBV

14

definition of BL

aggressive extranodal lymphoma and/or leukemia with propensity for CNS involvement

15

sites of involvement in endemic BL

facial bones, ileocecum, ovaries, kidneys, breast

16

sites of involvement in sporadic BL

abdominal masses most common, ovaries, kidneys, breast

17

sites of involvement in immunodeficiency related BL

lymph nodes and bone marrow

18

clinical features of burkitt lymphoma

rapid doubling time, high tumor burden, bulky disease, tumor lysis syndrome

19

BL prognosis

potentially curable but treatment needs to begin asap

20

BL morphology

monotonous infiltrate of medium sized cells. starry sky pattern with numerous tingible body macrophages, deeply basophilic cytoplasm with lipid vacuoles (red on oil red stain)

21

BL and Ki67

100% proliferative rate

22

derivation of burkitt lymphoma

germinal center b cell

23

immunophenotype of burkitt lymphoma

CD19/20+ (mature B cell)
CD5- (not t cell)
light chain restricted
CD10+, BCL+, BCL2- (not follicular!)

24

cause of burkitt lymphoma

tremendous proliferative drive due to EBV infection (those who are T cell immunodeficient can't clear), which leads to genetic accident/translocation and activation of cMYC via t(8;14)