Bone Marrow Flashcards Preview

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Flashcards in Bone Marrow Deck (12):
1

leukocytosis

increased WBCs

2

neutrophilia

leukocytosis of neutrophils specifically

3

reasons blood count could be disrupted

problems with synthesis in the bone marrow, problems with distribution, increased destruction/clearance/loss

4

what does looking at the bone marrow allow you to do?

rule in or out a production issue, monitor leukemia response to therapy, stage tumor (stage 4)

5

where is the most common location to take bone marrow?

iliac crest

6

what does an aspirate tell you?

morphology, ancillary studies. due to its dissociated cells, can get flow cytometry information and genetic studies

7

what can a bone marrow biopsy tell you?

architecture, spatial relations, cellularity. can use pieces for immunohistochemistry information

8

tests to determine immunophenotype

flow cytometry & immunohistochemistry

9

relationship of biopsy with age

with increasing age, hematopoietic elements decrease and fat accumulates. % cellularity=100-age (infant=100)

10

which cells do we look for in an aspirate?

granulocyte precursors (myeloid), erythroid precursors, megakaryocytes

11

myeloid maturation

oval nucleus to convoluted/segmented nucleus. chromatin condenses. cytoplasm acquires granules.

12

erythroid maturation

perfectly circular nuclei that is eventually expelled. cytoplasm gains hemoglobin.