Flashcards in Bone Marrow Deck (12):
leukocytosis of neutrophils specifically
reasons blood count could be disrupted
problems with synthesis in the bone marrow, problems with distribution, increased destruction/clearance/loss
what does looking at the bone marrow allow you to do?
rule in or out a production issue, monitor leukemia response to therapy, stage tumor (stage 4)
where is the most common location to take bone marrow?
what does an aspirate tell you?
morphology, ancillary studies. due to its dissociated cells, can get flow cytometry information and genetic studies
what can a bone marrow biopsy tell you?
architecture, spatial relations, cellularity. can use pieces for immunohistochemistry information
tests to determine immunophenotype
flow cytometry & immunohistochemistry
relationship of biopsy with age
with increasing age, hematopoietic elements decrease and fat accumulates. % cellularity=100-age (infant=100)
which cells do we look for in an aspirate?
granulocyte precursors (myeloid), erythroid precursors, megakaryocytes
oval nucleus to convoluted/segmented nucleus. chromatin condenses. cytoplasm acquires granules.