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Flashcards in NSAIDs Deck (14):
1

NSAIDs

Non Steroidal Anti-Inflammatory Drugs. Weak acids that inhibit cyclooxygenase (COX)

2

traditional NSAIDs

NSAIDs that non selectively inhibit both forms of COX (aspirin, ibuprofen, naproxen)

3

Coxibs

newer NSAIDs that have a greater selectivity for COX2 (don't have zero effect on COX1 though). names end in coxib

4

mechanism of action of aspirin

acetylates Ser-530 in COX1 and results in irreversible inhibition

5

only NSAID that is irreversible

Aspirin

6

mechanism of other NSAIDs

binds to enzyme's active site and elicits structural change which inactivates enzyme and is slowly reversible

7

why can't we use ibuprofen as anti platelet therapy for cardiovascular disease?

platelet aggregation is recoverable whereas with aspirin it is irreversible

8

clinical utility of NSAIDs (4As)

anti-pyretic, analgesic, anti-inflammatory, antiplatelet

9

side effects of NSAIDs

blocking cytoprotection results in gastropathy, blocking platelet activity results in bleeding, reduced renal vasodilation=hypertension, prolongation of gestation

10

gastropathy

inhibit homeostasis of healthy mucosa: increased gastric erosion while at the same time increasing bleeding

11

rofecoxib

selectively inhibited COX2 in order to only target inflammatory effects and reduce toxicities. worked but increased the risk for MI due to homeostasis imbalance of TxA2/PGI

12

low dose vs high dose of aspirin

low: inhibits platelets
high: analgesic, antiinflammatory

13

reyes syndrome

hepatic toxicity syndrome due to aspirin overdose

14

salicylism

salicylate toxicity due to aspirin. headache, tinnitus, dizziness, nausea. common pediatric overdose