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Flashcards in Hodgkin Lymphomas Deck (31):
1

acute leukemia morphology

immature cells (blasts)

2

chronic leukemia morphology

mature or maturing cells

3

acute leukemia cellular mechanism

maturation arrest

4

chronic leukemia cellular mechanism

increased proliferation or decreased apoptosis

5

acute leukemia clinical symptoms

bone marrow failure leads to bleeding, infections, fatigue

6

chronic leukemia clinical symptoms

nonspecific: organ infiltration, leukocytosis, late marrow failure

7

neoplastic cell in hodgkin lymphomas

reed sternburg cell: binucleated cell with prominent eosinophilic inclusion like nuclei. owl eyes

8

epidemiology of hodgkin lymphoma

uncommon, bimodal age curve (15-35 and 50+), both sexes evenly

9

clinical presentation of HL

painless lymphadenopathy (mostly cervical), fever, night sweats, weight loss, infections

10

pattern of HL spread

unifocal, contiguous, lymphatic spread. doesn't jump around. goes in order

11

characteristic of HL lymph node biopsy

less than 1% of cells will be reed stern burg cells. 99% are reactive, nonmalignant cellular infiltrate

12

origin of HL neoplasms

B cells from germinal center

13

classical HL

nodular sclerosis, mixed cellularity, lymphocyte depletion or enrichment. diffuse or nodular growth.

14

immunophenotype of classic HL

CD15+ (mature myeloid antigen)
CD30+ (not lineage specific)
PAX5+ (B cell)

15

nodular lymphocyte prodominant HL

only about 5% of HLs. nodular growth, popcorn like cells with small lymphocytic background

16

tage 1

one region

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stage 2

two regions but on same side of diaphragm

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stage 3

both sides of diaphragm. but confined to lymphatic system

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stage 4

disseminated beyond lymphatics

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hodgkin prognosis

function of stage, but typically 80% survival

21

definition of HL

lymphoma that contains a minority of neoplastic Reed-Sternburg cells and a much larger, pleomorphic background of non-neoplastic, reactive inflammatory cells

22

staging the disease

to determine how far the disease has disseminated throughout the body

23

EBV

herpes virus. might be causative or might be an epiphenomenon.

24

HL and NFkB

constitutive activity in HL. likely protects the cell from the hostile environment of the germinal center

25

B symptoms

constitutive symptoms (night sweats, fever, weight loss)

26

what is needed to diagnose?

a whole, intact, excisional lymph node biopsy

27

requirements to definitively diagnose HL

RS cell, presence of appropriate milieu of inflammatory cell background, nodal architecture effacement

28

most common type of classic HL

nodular sclerosis

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difference between therapeutic decisions in HL vs NHL

HL: based essentially on stage rather than classification

30

treatment of early stage HL

abbreviated course of combination chemotherapy followed by involved field radiotherapy

31

treatment of late stage HL

chemotherapy with radiotherapy sometimes